Sharoyko VV - Search Results

1

Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.

Sharoyko VV, Abels M, Sun J, Nicholas LM, Mollet IG, Stamenkovic JA, Göhring I, Malmgren S, Storm P, Fadista J, Spégel P, Metodiev MD, Larsson NG, Eliasson L, Wierup N, Mulder H. Sharoyko VV, et al. Hum Mol Genet. 2014 Nov 1;23(21):5733-49. doi: 10.1093/hmg/ddu288. Epub 2014 Jun 10. Hum Mol Genet. 2014. PMID: 24916378

2

Unique and Shared Metabolic Regulation in Clonal β-Cells and Primary Islets Derived From Rat Revealed by Metabolomics Analysis.

Spégel P, Andersson LE, Storm P, Sharoyko V, Göhring I, Rosengren AH, Mulder H. Spégel P, et al. Endocrinology. 2015 Jun;156(6):1995-2005. doi: 10.1210/en.2014-1391. Epub 2015 Mar 16. Endocrinology. 2015. PMID: 25774549

3

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.

Koeck T, Olsson AH, Nitert MD, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Rönn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG, Balhuizen A, Luthman H, Stančáková A, Kuusisto J, Laakso M, Poulsen P, Vaag A, Groop L, Lyssenko V, Mulder H, Ling C. Koeck T, et al. Among authors: sharoyko vv. Cell Metab. 2011 Jan 5;13(1):80-91. doi: 10.1016/j.cmet.2010.12.007. Cell Metab. 2011. PMID: 21195351 Free article.

4

The pathogenetic role of β-cell mitochondria in type 2 diabetes.

Fex M, Nicholas LM, Vishnu N, Medina A, Sharoyko VV, Nicholls DG, Spégel P, Mulder H. Fex M, et al. Among authors: sharoyko vv. J Endocrinol. 2018 Mar;236(3):R145-R159. doi: 10.1530/JOE-17-0367. J Endocrinol. 2018. PMID: 29431147 Review.

5

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.

Malmgren S, Nicholls DG, Taneera J, Bacos K, Koeck T, Tamaddon A, Wibom R, Groop L, Ling C, Mulder H, Sharoyko VV. Malmgren S, et al. Among authors: sharoyko vv. J Biol Chem. 2009 Nov 20;284(47):32395-404. doi: 10.1074/jbc.M109.026708. Epub 2009 Sep 21. J Biol Chem. 2009. PMID: 19797055 Free PMC article.

6

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.

Krus U, Kotova O, Spégel P, Hallgard E, Sharoyko VV, Vedin A, Moritz T, Sugden MC, Koeck T, Mulder H. Krus U, et al. Among authors: sharoyko vv. Biochem J. 2010 Jul 1;429(1):205-13. doi: 10.1042/BJ20100142. Biochem J. 2010. PMID: 20415663

7

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines.

Spégel P, Malmgren S, Sharoyko VV, Newsholme P, Koeck T, Mulder H. Spégel P, et al. Among authors: sharoyko vv. Biochem J. 2011 Apr 1;435(1):277-84. doi: 10.1042/BJ20100655. Biochem J. 2011. PMID: 21208194

8

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.

Spégel P, Sharoyko VV, Goehring I, Danielsson AP, Malmgren S, Nagorny CL, Andersson LE, Koeck T, Sharp GW, Straub SG, Wollheim CB, Mulder H. Spégel P, et al. Among authors: sharoyko vv. Biochem J. 2013 Mar 15;450(3):595-605. doi: 10.1042/BJ20121349. Biochem J. 2013. PMID: 23282133

9

The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration.

Kumar P, Sharoyko VV, Spégel P, Gullberg U, Mulder H, Olsson I, Ajore R. Kumar P, et al. Among authors: sharoyko vv. PLoS One. 2013 Jul 1;8(7):e68502. doi: 10.1371/journal.pone.0068502. Print 2013. PLoS One. 2013. PMID: 23840896 Free PMC article.

10

Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.

Göhring I, Sharoyko VV, Malmgren S, Andersson LE, Spégel P, Nicholls DG, Mulder H. Göhring I, et al. Among authors: sharoyko vv. J Biol Chem. 2014 Feb 7;289(6):3786-98. doi: 10.1074/jbc.M113.507335. Epub 2013 Dec 19. J Biol Chem. 2014. PMID: 24356960 Free PMC article.

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