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Exploring the UDP pocket of LpxC through amino acid analogs.
Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W. Hale MR, et al. Among authors: alm r. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2362-7. doi: 10.1016/j.bmcl.2013.02.055. Epub 2013 Mar 1. Bioorg Med Chem Lett. 2013. PMID: 23499237
In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria.
Huband MD, Bradford PA, Otterson LG, Basarab GS, Kutschke AC, Giacobbe RA, Patey SA, Alm RA, Johnstone MR, Potter ME, Miller PF, Mueller JP. Huband MD, et al. Among authors: alm ra. Antimicrob Agents Chemother. 2015 Jan;59(1):467-74. doi: 10.1128/AAC.04124-14. Epub 2014 Nov 10. Antimicrob Agents Chemother. 2015. PMID: 25385112 Free PMC article.
Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity.
Reck F, Alm R, Brassil P, Newman J, Dejonge B, Eyermann CJ, Breault G, Breen J, Comita-Prevoir J, Cronin M, Davis H, Ehmann D, Galullo V, Geng B, Grebe T, Morningstar M, Walker P, Hayter B, Fisher S. Reck F, et al. Among authors: alm r. J Med Chem. 2011 Nov 24;54(22):7834-47. doi: 10.1021/jm2008826. Epub 2011 Oct 27. J Med Chem. 2011. PMID: 21999508
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Basarab GS, Kern GH, McNulty J, Mueller JP, Lawrence K, Vishwanathan K, Alm RA, Barvian K, Doig P, Galullo V, Gardner H, Gowravaram M, Huband M, Kimzey A, Morningstar M, Kutschke A, Lahiri SD, Perros M, Singh R, Schuck VJ, Tommasi R, Walkup G, Newman JV. Basarab GS, et al. Among authors: alm ra. Sci Rep. 2015 Jul 14;5:11827. doi: 10.1038/srep11827. Sci Rep. 2015. PMID: 26168713 Free PMC article. Clinical Trial.
The CARB-X Portfolio of Nontraditional Antibacterial Products.
Duffy EM, Buurman ET, Chiang SL, Cohen NR, Uria-Nickelsen M, Alm RA. Duffy EM, et al. Among authors: alm ra. ACS Infect Dis. 2021 Aug 13;7(8):2043-2049. doi: 10.1021/acsinfecdis.1c00331. Epub 2021 Aug 4. ACS Infect Dis. 2021. PMID: 34346202
Helicobacter pylori physiology predicted from genomic comparison of two strains.
Doig P, de Jonge BL, Alm RA, Brown ED, Uria-Nickelsen M, Noonan B, Mills SD, Tummino P, Carmel G, Guild BC, Moir DT, Vovis GF, Trust TJ. Doig P, et al. Among authors: alm ra. Microbiol Mol Biol Rev. 1999 Sep;63(3):675-707. doi: 10.1128/MMBR.63.3.675-707.1999. Microbiol Mol Biol Rev. 1999. PMID: 10477312 Free PMC article. Review.
132 results