Eakin AE - Search Results

1

Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).

Basarab GS, Hill PJ, Garner CE, Hull K, Green O, Sherer BA, Dangel PB, Manchester JI, Bist S, Hauck S, Zhou F, Uria-Nickelsen M, Illingworth R, Alm R, Rooney M, Eakin AE. Basarab GS, et al. Among authors: eakin ae. J Med Chem. 2014 Jul 24;57(14):6060-82. doi: 10.1021/jm500462x. Epub 2014 Jul 8. J Med Chem. 2014. PMID: 24959892

2

Novel DNA gyrase inhibitors: microbiological characterisation of pyrrolamides.

Uria-Nickelsen M, Blodgett A, Kamp H, Eakin A, Sherer B, Green O. Uria-Nickelsen M, et al. Int J Antimicrob Agents. 2013 Jan;41(1):28-35. doi: 10.1016/j.ijantimicag.2012.08.017. Epub 2012 Nov 8. Int J Antimicrob Agents. 2013. PMID: 23142086

3

Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy.

Sherer BA, Hull K, Green O, Basarab G, Hauck S, Hill P, Loch JT 3rd, Mullen G, Bist S, Bryant J, Boriack-Sjodin A, Read J, DeGrace N, Uria-Nickelsen M, Illingworth RN, Eakin AE. Sherer BA, et al. Among authors: eakin ae. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7416-20. doi: 10.1016/j.bmcl.2011.10.010. Epub 2011 Oct 12. Bioorg Med Chem Lett. 2011. PMID: 22041057

4

Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.

Eakin AE, Green O, Hales N, Walkup GK, Bist S, Singh A, Mullen G, Bryant J, Embrey K, Gao N, Breeze A, Timms D, Andrews B, Uria-Nickelsen M, Demeritt J, Loch JT 3rd, Hull K, Blodgett A, Illingworth RN, Prince B, Boriack-Sjodin PA, Hauck S, MacPherson LJ, Ni H, Sherer B. Eakin AE, et al. Antimicrob Agents Chemother. 2012 Mar;56(3):1240-6. doi: 10.1128/AAC.05485-11. Epub 2011 Dec 19. Antimicrob Agents Chemother. 2012. PMID: 22183167 Free PMC article.

5

Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents.

Basarab GS, Manchester JI, Bist S, Boriack-Sjodin PA, Dangel B, Illingworth R, Sherer BA, Sriram S, Uria-Nickelsen M, Eakin AE. Basarab GS, et al. Among authors: eakin ae. J Med Chem. 2013 Nov 14;56(21):8712-35. doi: 10.1021/jm401208b. Epub 2013 Oct 29. J Med Chem. 2013. PMID: 24098982

6

Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.

Mills SD, Eakin AE, Buurman ET, Newman JV, Gao N, Huynh H, Johnson KD, Lahiri S, Shapiro AB, Walkup GK, Yang W, Stokes SS. Mills SD, et al. Among authors: eakin ae. Antimicrob Agents Chemother. 2011 Mar;55(3):1088-96. doi: 10.1128/AAC.01181-10. Epub 2010 Dec 28. Antimicrob Agents Chemother. 2011. PMID: 21189350 Free PMC article.

7

Pharmacokinetics/pharmacodynamics of a β-lactam and β-lactamase inhibitor combination: a novel approach for aztreonam/avibactam.

Singh R, Kim A, Tanudra MA, Harris JJ, McLaughlin RE, Patey S, O'Donnell JP, Bradford PA, Eakin AE. Singh R, et al. Among authors: eakin ae. J Antimicrob Chemother. 2015 Sep;70(9):2618-26. doi: 10.1093/jac/dkv132. Epub 2015 May 29. J Antimicrob Chemother. 2015. PMID: 26024868

8

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy.

Kim A, Kutschke A, Ehmann DE, Patey SA, Crandon JL, Gorseth E, Miller AA, McLaughlin RE, Blinn CM, Chen A, Nayar AS, Dangel B, Tsai AS, Rooney MT, Murphy-Benenato KE, Eakin AE, Nicolau DP. Kim A, et al. Among authors: eakin ae. Antimicrob Agents Chemother. 2015 Dec;59(12):7743-52. doi: 10.1128/AAC.00831-15. Epub 2015 Oct 5. Antimicrob Agents Chemother. 2015. PMID: 26438502 Free PMC article.

9

A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase.

Shapiro AB, Eakin AE, Walkup GK, Rivin O. Shapiro AB, et al. Among authors: eakin ae. J Biomol Screen. 2011 Jun;16(5):486-93. doi: 10.1177/1087057111398295. Epub 2011 Mar 11. J Biomol Screen. 2011. PMID: 21398623

10

Considerations for Dose Selection and Clinical Pharmacokinetics/Pharmacodynamics for the Development of Antibacterial Agents.

Rizk ML, Bhavnani SM, Drusano G, Dane A, Eakin AE, Guina T, Jang SH, Tomayko JF, Wang J, Zhuang L, Lodise TP. Rizk ML, et al. Among authors: eakin ae. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02309-18. doi: 10.1128/AAC.02309-18. Print 2019 May. Antimicrob Agents Chemother. 2019. PMID: 30833427 Free PMC article. Review.

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