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CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.
Fløyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, Størling J, Pociot F. Fløyel T, et al. Among authors: morahan g. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10. doi: 10.1073/pnas.1402571111. Epub 2014 Jun 30. Proc Natl Acad Sci U S A. 2014. PMID: 24982147 Free PMC article. Clinical Trial.
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, Bergholdt R, Akolkar B, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras CR, Chen WM, Rich SS; Type 1 Diabetes Genetics Consortium. Concannon P, et al. Among authors: morahan g. Diabetes. 2008 Oct;57(10):2858-61. doi: 10.2337/db08-0753. Epub 2008 Jul 22. Diabetes. 2008. PMID: 18647951 Free PMC article.
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS; Type 1 Diabetes Genetics Consortium. Barrett JC, et al. Among authors: morahan g. Nat Genet. 2009 Jun;41(6):703-7. doi: 10.1038/ng.381. Epub 2009 May 10. Nat Genet. 2009. PMID: 19430480 Free PMC article.
Overview of the Type I Diabetes Genetics Consortium.
Rich SS, Akolkar B, Concannon P, Erlich H, Hilner JE, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd JA. Rich SS, et al. Among authors: morahan g. Genes Immun. 2009 Dec;10 Suppl 1(Suppl 1):S1-4. doi: 10.1038/gene.2009.84. Genes Immun. 2009. PMID: 19956093 Free PMC article.
Current status and the future for the genetics of type I diabetes.
Rich SS, Akolkar B, Concannon P, Erlich H, Hilner JE, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd JA. Rich SS, et al. Among authors: morahan g. Genes Immun. 2009 Dec;10 Suppl 1(Suppl 1):S128-31. doi: 10.1038/gene.2009.100. Genes Immun. 2009. PMID: 19956094 Free PMC article.
rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype.
Steck AK, Baschal EE, Jasinski JM, Boehm BO, Bottini N, Concannon P, Julier C, Morahan G, Noble JA, Polychronakos C, She JX, Eisenbarth GS; Type I Diabetes Genetics Consortium. Steck AK, et al. Among authors: morahan g. Genes Immun. 2009 Dec;10 Suppl 1(Suppl 1):S21-6. doi: 10.1038/gene.2009.87. Genes Immun. 2009. PMID: 19956096 Free PMC article.
235 results