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Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.
Darrah PA, Bolton DL, Lackner AA, Kaushal D, Aye PP, Mehra S, Blanchard JL, Didier PJ, Roy CJ, Rao SS, Hokey DA, Scanga CA, Sizemore DR, Sadoff JC, Roederer M, Seder RA. Darrah PA, et al. Among authors: sizemore dr. J Immunol. 2014 Aug 15;193(4):1799-811. doi: 10.4049/jimmunol.1400676. Epub 2014 Jul 14. J Immunol. 2014. PMID: 25024382 Free PMC article.
A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs.
Hokey DA, Wachholder R, Darrah PA, Bolton DL, Barouch DH, Hill K, Dheenadhayalan V, Schwander S, Godin CS, Douoguih M, Pau MG, Seder RA, Roederer M, Sadoff JC, Sizemore D. Hokey DA, et al. Hum Vaccin Immunother. 2014;10(8):2199-210. doi: 10.4161/hv.29108. Hum Vaccin Immunother. 2014. PMID: 25424923 Free PMC article.
Prime-boost vaccination with rBCG/rAd35 enhances CD8⁺ cytolytic T-cell responses in lesions from Mycobacterium tuberculosis-infected primates.
Rahman S, Magalhaes I, Rahman J, Ahmed RK, Sizemore DR, Scanga CA, Weichold F, Verreck F, Kondova I, Sadoff J, Thorstensson R, Spångberg M, Svensson M, Andersson J, Maeurer M, Brighenti S. Rahman S, et al. Among authors: sizemore dr. Mol Med. 2012 May 9;18(1):647-58. doi: 10.2119/molmed.2011.00222. Mol Med. 2012. PMID: 22396020 Free PMC article.
The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults.
Abel B, Tameris M, Mansoor N, Gelderbloem S, Hughes J, Abrahams D, Makhethe L, Erasmus M, de Kock M, van der Merwe L, Hawkridge A, Veldsman A, Hatherill M, Schirru G, Pau MG, Hendriks J, Weverling GJ, Goudsmit J, Sizemore D, McClain JB, Goetz M, Gearhart J, Mahomed H, Hussey GD, Sadoff JC, Hanekom WA. Abel B, et al. Am J Respir Crit Care Med. 2010 Jun 15;181(12):1407-17. doi: 10.1164/rccm.200910-1484OC. Epub 2010 Feb 18. Am J Respir Crit Care Med. 2010. PMID: 20167847 Free PMC article. Clinical Trial.
rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector.
Magalhaes I, Sizemore DR, Ahmed RK, Mueller S, Wehlin L, Scanga C, Weichold F, Schirru G, Pau MG, Goudsmit J, Kühlmann-Berenzon S, Spångberg M, Andersson J, Gaines H, Thorstensson R, Skeiky YA, Sadoff J, Maeurer M. Magalhaes I, et al. Among authors: sizemore dr. PLoS One. 2008;3(11):e3790. doi: 10.1371/journal.pone.0003790. Epub 2008 Nov 21. PLoS One. 2008. PMID: 19023426 Free PMC article.
High content cellular immune profiling reveals differences between rhesus monkeys and men.
Magalhaes I, Vudattu NK, Ahmed RK, Kühlmann-Berenzon S, Ngo Y, Sizemore DR, Wehlin L, Weichold F, Andersson J, Skeiky YA, Sadoff J, Gaines H, Thorstensson R, Spångberg M, Maeurer MJ. Magalhaes I, et al. Among authors: sizemore dr. Immunology. 2010 Sep;131(1):128-40. doi: 10.1111/j.1365-2567.2010.03284.x. Epub 2010 May 10. Immunology. 2010. PMID: 20465573 Free PMC article.
30 results