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Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.
Narayanapillai SC, Balbo S, Leitzman P, Grill AE, Upadhyaya P, Shaik AA, Zhou B, O'Sullivan MG, Peterson LA, Lu J, Hecht SS, Xing C. Narayanapillai SC, et al. Among authors: shaik aa. Carcinogenesis. 2014 Oct;35(10):2365-72. doi: 10.1093/carcin/bgu149. Epub 2014 Jul 22. Carcinogenesis. 2014. PMID: 25053626 Free PMC article.
Penta-O-galloyl-beta-D-glucose induces G1 arrest and DNA replicative S-phase arrest independently of cyclin-dependent kinase inhibitor 1A, cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth.
Chai Y, Lee HJ, Shaik AA, Nkhata K, Xing C, Zhang J, Jeong SJ, Kim SH, Lu J. Chai Y, et al. Among authors: shaik aa. Breast Cancer Res. 2010;12(5):R67. doi: 10.1186/bcr2634. Epub 2010 Sep 1. Breast Cancer Res. 2010. PMID: 20809980 Free PMC article.
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