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A chemical strategy for the cell-based detection of HDAC activity.
Diyabalanage HV, Van de Bittner GC, Ricq EL, Hooker JM. Diyabalanage HV, et al. Among authors: van de bittner gc. ACS Chem Biol. 2014 Jun 20;9(6):1257-62. doi: 10.1021/cb500248r. Epub 2014 Apr 30. ACS Chem Biol. 2014. PMID: 25056147 Free PMC article.
PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.
Schroeder FA, Wang C, Van de Bittner GC, Neelamegam R, Takakura WR, Karunakaran A, Wey HY, Reis SA, Gale J, Zhang YL, Holson EB, Haggarty SJ, Hooker JM. Schroeder FA, et al. Among authors: van de bittner gc. ACS Chem Neurosci. 2014 Oct 15;5(10):1055-62. doi: 10.1021/cn500162j. Epub 2014 Sep 19. ACS Chem Neurosci. 2014. PMID: 25188794 Free PMC article.
A philosophy for CNS radiotracer design.
Van de Bittner GC, Ricq EL, Hooker JM. Van de Bittner GC, et al. Acc Chem Res. 2014 Oct 21;47(10):3127-34. doi: 10.1021/ar500233s. Epub 2014 Oct 1. Acc Chem Res. 2014. PMID: 25272291 Free PMC article. Review.
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.
Weïwer M, Xu Q, Gale JP, Lewis M, Campbell AJ, Schroeder FA, Van de Bittner GC, Walk M, Amaya A, Su P, D Ordevic L, Sacher JR, Skepner A, Fei D, Dennehy K, Nguyen S, Faloon PW, Perez J, Cottrell JR, Liu F, Palmer M, Pan JQ, Hooker JM, Zhang YL, Scolnick E, Wagner FF, Holson EB. Weïwer M, et al. Among authors: van de bittner gc. ACS Chem Biol. 2018 Apr 20;13(4):1038-1047. doi: 10.1021/acschembio.8b00168. Epub 2018 Mar 14. ACS Chem Biol. 2018. PMID: 29485852
Nasal neuron PET imaging quantifies neuron generation and degeneration.
Van de Bittner GC, Riley MM, Cao L, Ehses J, Herrick SP, Ricq EL, Wey HY, O'Neill MJ, Ahmed Z, Murray TK, Smith JE, Wang C, Schroeder FA, Albers MW, Hooker JM. Van de Bittner GC, et al. J Clin Invest. 2017 Feb 1;127(2):681-694. doi: 10.1172/JCI89162. Epub 2017 Jan 23. J Clin Invest. 2017. PMID: 28112682 Free PMC article.
15 results