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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, Tang A, Raj T, Replogle J, Brodeur W, Gabriel S, Chai HS, Younkin C, Younkin SG, Zou F, Szyf M, Epstein CB, Schneider JA, Bernstein BE, Meissner A, Ertekin-Taner N, Chibnik LB, Kellis M, Mill J, Bennett DA. De Jager PL, et al. Among authors: schalkwyk lc. Nat Neurosci. 2014 Sep;17(9):1156-63. doi: 10.1038/nn.3786. Epub 2014 Aug 17. Nat Neurosci. 2014. PMID: 25129075 Free PMC article.
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, Condliffe D, Harries LW, Katsel P, Haroutunian V, Kaminsky Z, Joachim C, Powell J, Lovestone S, Bennett DA, Schalkwyk LC, Mill J. Lunnon K, et al. Among authors: schalkwyk lc. Nat Neurosci. 2014 Sep;17(9):1164-70. doi: 10.1038/nn.3782. Epub 2014 Aug 17. Nat Neurosci. 2014. PMID: 25129077 Free PMC article.
A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, Giese A, Sharp AJ, Schalkwyk L, Haroutunian V, Viechtbauer W, van den Hove DLA, Weedon M, Brokaw D, Francis PT, Thomas AJ, Love S, Morgan K, Walter J, Coleman PD, Bennett DA, De Jager PL, Mill J, Lunnon K. Smith RG, et al. Nat Commun. 2021 Jun 10;12(1):3517. doi: 10.1038/s41467-021-23243-4. Nat Commun. 2021. PMID: 34112773 Free PMC article.
A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex.
Marzi SJ, Leung SK, Ribarska T, Hannon E, Smith AR, Pishva E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, Lunnon K, Schalkwyk LC, Mill J. Marzi SJ, et al. Among authors: schalkwyk lc. Nat Neurosci. 2018 Nov;21(11):1618-1627. doi: 10.1038/s41593-018-0253-7. Epub 2018 Oct 22. Nat Neurosci. 2018. PMID: 30349106
Tissue-specific patterns of allelically-skewed DNA methylation.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J. Marzi SJ, et al. Among authors: schalkwyk lc. Epigenetics. 2016;11(1):24-35. doi: 10.1080/15592294.2015.1127479. Epub 2016 Jan 19. Epigenetics. 2016. PMID: 26786711 Free PMC article.
Intermediate DNA methylation is a conserved signature of genome regulation.
Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, Mill J, Farnham PJ, Kellis M, Marra MA, Milosavljevic A, Hirst M, Stormo GD, Wang T, Costello JF. Elliott G, et al. Among authors: schalkwyk lc. Nat Commun. 2015 Feb 18;6:6363. doi: 10.1038/ncomms7363. Nat Commun. 2015. PMID: 25691127 Free PMC article.
142 results