Fedeles BI - Search Results

1

Mechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ketoglutarate/Fe(II) dioxygenase AlkB.

Singh V, Fedeles BI, Li D, Delaney JC, Kozekov ID, Kozekova A, Marnett LJ, Rizzo CJ, Essigmann JM. Singh V, et al. Among authors: fedeles bi. Chem Res Toxicol. 2014 Sep 15;27(9):1619-31. doi: 10.1021/tx5002817. Epub 2014 Aug 26. Chem Res Toxicol. 2014. PMID: 25157679 Free PMC article.

2

Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents.

Sharma U, Marquis JC, Nicole Dinaut A, Hillier SM, Fedeles B, Rye PT, Essigmann JM, Croy RG. Sharma U, et al. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3829-33. doi: 10.1016/j.bmcl.2004.04.064. Bioorg Med Chem Lett. 2004. PMID: 15203171 Free PMC article.

3

Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target.

Fedeles BI, Zhu AY, Young KS, Hillier SM, Proffitt KD, Essigmann JM, Croy RG. Fedeles BI, et al. J Biol Chem. 2011 Sep 30;286(39):33910-20. doi: 10.1074/jbc.M111.278390. Epub 2011 Aug 10. J Biol Chem. 2011. PMID: 21832047 Free PMC article.

4

Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB.

Li D, Fedeles BI, Shrivastav N, Delaney JC, Yang X, Wong C, Drennan CL, Essigmann JM. Li D, et al. Among authors: fedeles bi. Chem Res Toxicol. 2013 Aug 19;26(8):1182-7. doi: 10.1021/tx400096m. Epub 2013 Jul 10. Chem Res Toxicol. 2013. PMID: 23773213 Free PMC article.

5

A chemical genetics analysis of the roles of bypass polymerase DinB and DNA repair protein AlkB in processing N2-alkylguanine lesions in vivo.

Shrivastav N, Fedeles BI, Li D, Delaney JC, Frick LE, Foti JJ, Walker GC, Essigmann JM. Shrivastav N, et al. Among authors: fedeles bi. PLoS One. 2014 Apr 14;9(4):e94716. doi: 10.1371/journal.pone.0094716. eCollection 2014. PLoS One. 2014. PMID: 24733044 Free PMC article.

6

Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine.

Li D, Fedeles BI, Singh V, Peng CS, Silvestre KJ, Simi AK, Simpson JH, Tokmakoff A, Essigmann JM. Li D, et al. Among authors: fedeles bi. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3252-9. doi: 10.1073/pnas.1405635111. Epub 2014 Jul 28. Proc Natl Acad Sci U S A. 2014. PMID: 25071207 Free PMC article.

7

Role of tautomerism in RNA biochemistry.

Singh V, Fedeles BI, Essigmann JM. Singh V, et al. Among authors: fedeles bi. RNA. 2015 Jan;21(1):1-13. doi: 10.1261/rna.048371.114. RNA. 2015. PMID: 25516996 Free PMC article. Review.

8

Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity.

Peng CS, Fedeles BI, Singh V, Li D, Amariuta T, Essigmann JM, Tokmakoff A. Peng CS, et al. Among authors: fedeles bi. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3229-34. doi: 10.1073/pnas.1415974112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733867 Free PMC article.

9

Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo.

Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, Essigmann JM. Chang SC, et al. Among authors: fedeles bi. Nucleic Acids Res. 2015 Jun 23;43(11):5489-500. doi: 10.1093/nar/gkv243. Epub 2015 Apr 2. Nucleic Acids Res. 2015. PMID: 25837992 Free PMC article.

10

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.

Fedeles BI, Singh V, Delaney JC, Li D, Essigmann JM. Fedeles BI, et al. J Biol Chem. 2015 Aug 21;290(34):20734-20742. doi: 10.1074/jbc.R115.656462. Epub 2015 Jul 7. J Biol Chem. 2015. PMID: 26152727 Free PMC article. Review.

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