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Activated d16HER2 homodimers and SRC kinase mediate optimal efficacy for trastuzumab.
Castagnoli L, Iezzi M, Ghedini GC, Ciravolo V, Marzano G, Lamolinara A, Zappasodi R, Gasparini P, Campiglio M, Amici A, Chiodoni C, Palladini A, Lollini PL, Triulzi T, Menard S, Nanni P, Tagliabue E, Pupa SM. Castagnoli L, et al. Cancer Res. 2014 Nov 1;74(21):6248-59. doi: 10.1158/0008-5472.CAN-14-0983. Epub 2014 Aug 27. Cancer Res. 2014. PMID: 25164009
The human splice variant Δ16HER2 induces rapid tumor onset in a reporter transgenic mouse.
Marchini C, Gabrielli F, Iezzi M, Zenobi S, Montani M, Pietrella L, Kalogris C, Rossini A, Ciravolo V, Castagnoli L, Tagliabue E, Pupa SM, Musiani P, Monaci P, Menard S, Amici A. Marchini C, et al. Among authors: castagnoli l. PLoS One. 2011 Apr 29;6(4):e18727. doi: 10.1371/journal.pone.0018727. PLoS One. 2011. PMID: 21559085 Free PMC article.
Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients: the AMNESIA Case-Control Study.
Pietrantonio F, Fucà G, Morano F, Gloghini A, Corso S, Aprile G, Perrone F, De Vita F, Tamborini E, Tomasello G, Gualeni AV, Ongaro E, Busico A, Giommoni E, Volpi CC, Laterza MM, Corallo S, Prisciandaro M, Antista M, Pellegrinelli A, Castagnoli L, Pupa SM, Pruneri G, de Braud F, Giordano S, Cremolini C, Di Bartolomeo M. Pietrantonio F, et al. Among authors: castagnoli l. Clin Cancer Res. 2018 Mar 1;24(5):1082-1089. doi: 10.1158/1078-0432.CCR-17-2781. Epub 2017 Dec 5. Clin Cancer Res. 2018. PMID: 29208673 Free article.
The landscape of d16HER2 splice variant expression across HER2-positive cancers.
Volpi CC, Pietrantonio F, Gloghini A, Fucà G, Giordano S, Corso S, Pruneri G, Antista M, Cremolini C, Fasano E, Saggio S, Faraci S, Di Bartolomeo M, de Braud F, Di Nicola M, Tagliabue E, Pupa SM, Castagnoli L. Volpi CC, et al. Among authors: castagnoli l. Sci Rep. 2019 Mar 5;9(1):3545. doi: 10.1038/s41598-019-40310-5. Sci Rep. 2019. PMID: 30837627 Free PMC article.
Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.
Koschorke A, Faraci S, Giani D, Chiodoni C, Iorio E, Canese R, Colombo MP, Lamolinara A, Iezzi M, Ladomery M, Vernieri C, de Braud F, Di Nicola M, Tagliabue E, Castagnoli L, Pupa SM. Koschorke A, et al. Among authors: castagnoli l. Cell Oncol (Dordr). 2019 Dec;42(6):815-828. doi: 10.1007/s13402-019-00464-w. Epub 2019 Aug 2. Cell Oncol (Dordr). 2019. PMID: 31376137
158 results