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Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels.
Kumar V, Gutierrez-Achury J, Kanduri K, Almeida R, Hrdlickova B, Zhernakova DV, Westra HJ, Karjalainen J, Ricaño-Ponce I, Li Y, Stachurska A, Tigchelaar EF, Abdulahad WH, Lähdesmäki H, Hofker MH, Zhernakova A, Franke L, Lahesmaa R, Wijmenga C, Withoff S. Kumar V, et al. Among authors: lahdesmaki h. Hum Mol Genet. 2015 Jan 15;24(2):397-409. doi: 10.1093/hmg/ddu453. Epub 2014 Sep 4. Hum Mol Genet. 2015. PMID: 25190711
An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation.
Aijö T, Edelman SM, Lönnberg T, Larjo A, Kallionpää H, Tuomela S, Engström E, Lahesmaa R, Lähdesmäki H. Aijö T, et al. Among authors: lahdesmaki h. BMC Genomics. 2012 Oct 30;13:572. doi: 10.1186/1471-2164-13-572. BMC Genomics. 2012. PMID: 23110343 Free PMC article.
Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.
Tahvanainen J, Kyläniemi MK, Kanduri K, Gupta B, Lähteenmäki H, Kallonen T, Rajavuori A, Rasool O, Koskinen PJ, Rao KV, Lähdesmäki H, Lahesmaa R. Tahvanainen J, et al. Among authors: lahdesmaki h. J Biol Chem. 2013 Feb 1;288(5):3048-58. doi: 10.1074/jbc.M112.361709. Epub 2012 Dec 3. J Biol Chem. 2013. PMID: 23209281 Free PMC article.
Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.
Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R. Kallionpää H, et al. Among authors: lahdesmaki h. Diabetes. 2014 Jul;63(7):2402-14. doi: 10.2337/db13-1775. Epub 2014 Feb 18. Diabetes. 2014. PMID: 24550192 Free article.
130 results