Thresher J - Search Results

1

Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain.

Gao N, McLeod SM, Hajec L, Olivier NB, Lahiri SD, Bryan Prince D, Thresher J, Ross PL, Whiteaker JD, Doig P, Li AH, Hill PJ, Cornebise M, Reck F, Hale MR. Gao N, et al. Among authors: thresher j. Protein Expr Purif. 2014 Dec;104:57-64. doi: 10.1016/j.pep.2014.09.006. Epub 2014 Sep 18. Protein Expr Purif. 2014. PMID: 25240855

2

Exploring the UDP pocket of LpxC through amino acid analogs.

Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W. Hale MR, et al. Among authors: thresher j. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2362-7. doi: 10.1016/j.bmcl.2013.02.055. Epub 2013 Mar 1. Bioorg Med Chem Lett. 2013. PMID: 23499237

3

Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.

Nayar AS, Dougherty TJ, Reck F, Thresher J, Gao N, Shapiro AB, Ehmann DE. Nayar AS, et al. Among authors: thresher j. Antimicrob Agents Chemother. 2015 Jan;59(1):331-7. doi: 10.1128/AAC.04077-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348539 Free PMC article.

4

A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase.

Shapiro AB, Gao N, Thresher J, Walkup GK, Whiteaker J. Shapiro AB, et al. Among authors: thresher j. J Biomol Screen. 2011 Jun;16(5):494-505. doi: 10.1177/1087057111398934. Epub 2011 Mar 14. J Biomol Screen. 2011. PMID: 21402755

5

A high-throughput-compatible fluorescence anisotropy-based assay for competitive inhibitors of Escherichia coli UDP-N-acetylglucosamine acyltransferase (LpxA).

Shapiro AB, Ross PL, Gao N, Livchak S, Kern G, Yang W, Andrews B, Thresher J. Shapiro AB, et al. Among authors: thresher j. J Biomol Screen. 2013 Mar;18(3):341-7. doi: 10.1177/1087057112462062. Epub 2012 Sep 26. J Biomol Screen. 2013. PMID: 23015018

6

Kinetics of avibactam inhibition against Class A, C, and D β-lactamases.

Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Durand-Réville TF, Lahiri S, Thresher J, Livchak S, Gao N, Palmer T, Walkup GK, Fisher SL. Ehmann DE, et al. Among authors: thresher j. J Biol Chem. 2013 Sep 27;288(39):27960-71. doi: 10.1074/jbc.M113.485979. Epub 2013 Aug 2. J Biol Chem. 2013. PMID: 23913691 Free PMC article.

7

Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.

Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET. Hill PJ, et al. Among authors: thresher j. J Med Chem. 2013 Sep 26;56(18):7278-88. doi: 10.1021/jm400718n. Epub 2013 Sep 17. J Med Chem. 2013. PMID: 23981144

8

Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.

Shapiro AB, Gao N, Gu RF, Thresher J. Shapiro AB, et al. Among authors: thresher j. Anal Biochem. 2014 Oct 15;463:15-22. doi: 10.1016/j.ab.2014.06.004. Epub 2014 Jun 16. Anal Biochem. 2014. PMID: 24945954

9

Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.

Murphy-Benenato KE, Olivier N, Choy A, Ross PL, Miller MD, Thresher J, Gao N, Hale MR. Murphy-Benenato KE, et al. Among authors: thresher j. ACS Med Chem Lett. 2014 Sep 23;5(11):1213-8. doi: 10.1021/ml500210x. eCollection 2014 Nov 13. ACS Med Chem Lett. 2014. PMID: 25408833 Free PMC article.

10

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC.

Lahiri SD, Walkup GK, Whiteaker JD, Palmer T, McCormack K, Tanudra MA, Nash TJ, Thresher J, Johnstone MR, Hajec L, Livchak S, McLaughlin RE, Alm RA. Lahiri SD, et al. Among authors: thresher j. J Antimicrob Chemother. 2015;70(6):1650-8. doi: 10.1093/jac/dkv004. Epub 2015 Feb 1. J Antimicrob Chemother. 2015. PMID: 25645206

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