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Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation.
Gil MA, Caniga M, Woodhouse JD, Eckman J, Lee HH, Salmon M, Naber J, Hamilton VT, Sevilla RS, Bettano K, Klappenbach J, Moy L, Correll CC, Gervais FG, Siliphaivanh P, Zhang W, Zhang-Hoover J, McLeod RL, Cicmil M. Gil MA, et al. Among authors: mcleod rl. Eur J Pharmacol. 2014 Nov 15;743:106-16. doi: 10.1016/j.ejphar.2014.09.021. Epub 2014 Sep 23. Eur J Pharmacol. 2014. PMID: 25261040 Free article.
Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models.
Lieber GB, Fernandez X, Mingo GG, Jia Y, Caniga M, Gil MA, Keshwani S, Woodhouse JD, Cicmil M, Moy LY, Kelly N, Jimenez J, Crawley Y, Anthes JC, Klappenbach J, Ma YL, McLeod RL. Lieber GB, et al. Among authors: mcleod rl. Eur J Pharmacol. 2013 Oct 15;718(1-3):290-8. doi: 10.1016/j.ejphar.2013.08.019. Epub 2013 Sep 5. Eur J Pharmacol. 2013. PMID: 24012780
Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis.
Chakravarthy K, Faltus R, Robinson G, Sevilla R, Shin J, Zielstorff M, Byford A, Leccese E, Caniga MJ, Hseih S, Zhang S, Chiu CS, Zhang-Hoover J, Moy LY, McLeod RL, Stoffregen D, Zhang W, Murtaza A, Cicmil M. Chakravarthy K, et al. Among authors: mcleod rl. BMC Musculoskelet Disord. 2014 Dec 4;15:409. doi: 10.1186/1471-2474-15-409. BMC Musculoskelet Disord. 2014. PMID: 25477192 Free PMC article.
Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions.
Caniga M, Cabal A, Mehta K, Ross DS, Gil MA, Woodhouse JD, Eckman J, Naber JR, Callahan MK, Goncalves L, Hill SE, Mcleod RL, McIntosh F, Freke MC, Visser SA, Johnson N, Salmon M, Cicmil M. Caniga M, et al. Among authors: mcleod rl. J Aerosol Med Pulm Drug Deliv. 2016 Aug;29(4):362-77. doi: 10.1089/jamp.2015.1253. Epub 2016 Feb 9. J Aerosol Med Pulm Drug Deliv. 2016. PMID: 26859446
Characterizing Pharmacokinetic-Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation.
McLeod RL, Gil MA, Chen D, Cabal A, Katz J, Methot J, Woodhouse JD, Dorosh L, Geda P, Mehta K, Cicmil M, Baltus GA, Bass A, Houshyar H, Caniga M, Yu H, Gervais F, Alves S, Shah S. McLeod RL, et al. J Pharmacol Exp Ther. 2019 May;369(2):223-233. doi: 10.1124/jpet.118.252551. Epub 2019 Feb 25. J Pharmacol Exp Ther. 2019. PMID: 30804001
TRPV1 antagonists as potential antitussive agents.
McLeod RL, Correll CC, Jia Y, Anthes JC. McLeod RL, et al. Lung. 2008;186 Suppl 1:S59-65. doi: 10.1007/s00408-007-9032-z. Epub 2007 Oct 10. Lung. 2008. PMID: 17926096 Review.
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators.
Methot JL, Zhou H, McGowan MA, Anthony NJ, Christopher M, Garcia Y, Achab A, Lipford K, Trotter BW, Altman MD, Fradera X, Lesburg CA, Li C, Alves S, Chappell CP, Jain R, Mangado R, Pinheiro E, Williams SMG, Goldenblatt P, Hill A, Shaffer L, Chen D, Tong V, McLeod RL, Lee HH, Yu H, Shah S, Katz JD. Methot JL, et al. Among authors: mcleod rl. J Med Chem. 2021 Apr 22;64(8):5137-5156. doi: 10.1021/acs.jmedchem.1c00237. Epub 2021 Apr 2. J Med Chem. 2021. PMID: 33797901
79 results