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Genome-wide discovery of drug-dependent human liver regulatory elements.
Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N. Smith RP, et al. Among authors: giacomini km. PLoS Genet. 2014 Oct 2;10(10):e1004648. doi: 10.1371/journal.pgen.1004648. eCollection 2014 Oct. PLoS Genet. 2014. PMID: 25275310 Free PMC article.
The pharmacogenetics research network: from SNP discovery to clinical drug response.
Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I; Pharmacogenetics Research Network. Giacomini KM, et al. Clin Pharmacol Ther. 2007 Mar;81(3):328-45. doi: 10.1038/sj.clpt.6100087. Clin Pharmacol Ther. 2007. PMID: 17339863 Free PMC article. Review.
Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).
Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM. Yee SW, et al. Among authors: giacomini km. J Pharmacol Exp Ther. 2009 Mar;328(3):699-707. doi: 10.1124/jpet.108.147207. Epub 2008 Dec 19. J Pharmacol Exp Ther. 2009. PMID: 19098160 Free PMC article.
Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.
Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM. Hesselson SE, et al. Among authors: giacomini km. PLoS One. 2009 Sep 9;4(9):e6942. doi: 10.1371/journal.pone.0006942. PLoS One. 2009. PMID: 19742321 Free PMC article.
Consequences of POR mutations and polymorphisms.
Miller WL, Agrawal V, Sandee D, Tee MK, Huang N, Choi JH, Morrissey K, Giacomini KM. Miller WL, et al. Among authors: giacomini km. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):174-9. doi: 10.1016/j.mce.2010.10.022. Epub 2010 Nov 9. Mol Cell Endocrinol. 2011. PMID: 21070833 Free PMC article.
Functional characterization of liver enhancers that regulate drug-associated transporters.
Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N. Kim MJ, et al. Among authors: giacomini km. Clin Pharmacol Ther. 2011 Apr;89(4):571-8. doi: 10.1038/clpt.2010.353. Epub 2011 Mar 2. Clin Pharmacol Ther. 2011. PMID: 21368754 Free PMC article.
The UCSF-FDA TransPortal: a public drug transporter database.
Morrissey KM, Wen CC, Johns SJ, Zhang L, Huang SM, Giacomini KM. Morrissey KM, et al. Among authors: giacomini km. Clin Pharmacol Ther. 2012 Nov;92(5):545-6. doi: 10.1038/clpt.2012.44. Clin Pharmacol Ther. 2012. PMID: 23085876 Free PMC article.
349 results