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Page 1
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia.
Rajala HL, Olson T, Clemente MJ, Lagström S, Ellonen P, Lundan T, Hamm DE, Zaman SA, Lopez Marti JM, Andersson EI, Jerez A, Porkka K, Maciejewski JP, Loughran TP, Mustjoki S. Rajala HL, et al. Haematologica. 2015 Jan;100(1):91-9. doi: 10.3324/haematol.2014.113142. Epub 2014 Oct 3. Haematologica. 2015. PMID: 25281507 Free PMC article.
Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia.
Andersson E, Kuusanmäki H, Bortoluzzi S, Lagström S, Parsons A, Rajala H, van Adrichem A, Eldfors S, Olson T, Clemente MJ, Laasonen A, Ellonen P, Heckman C, Loughran TP, Maciejewski JP, Mustjoki S. Andersson E, et al. Leukemia. 2016 May;30(5):1204-8. doi: 10.1038/leu.2015.263. Epub 2015 Sep 30. Leukemia. 2016. PMID: 26419508 Free PMC article. No abstract available.
STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.
Jerez A, Clemente MJ, Makishima H, Rajala H, Gómez-Seguí I, Olson T, McGraw K, Przychodzen B, Kulasekararaj A, Afable M, Husseinzadeh HD, Hosono N, LeBlanc F, Lagström S, Zhang D, Ellonen P, Tichelli A, Nissen C, Lichtin AE, Wodnar-Filipowicz A, Mufti GJ, List AF, Mustjoki S, Loughran TP Jr, Maciejewski JP. Jerez A, et al. Blood. 2013 Oct 3;122(14):2453-9. doi: 10.1182/blood-2013-04-494930. Epub 2013 Aug 7. Blood. 2013. PMID: 23926297 Free PMC article.
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.
Rajala HL, Eldfors S, Kuusanmäki H, van Adrichem AJ, Olson T, Lagström S, Andersson EI, Jerez A, Clemente MJ, Yan Y, Zhang D, Awwad A, Ellonen P, Kallioniemi O, Wennerberg K, Porkka K, Maciejewski JP, Loughran TP Jr, Heckman C, Mustjoki S. Rajala HL, et al. Blood. 2013 May 30;121(22):4541-50. doi: 10.1182/blood-2012-12-474577. Epub 2013 Apr 17. Blood. 2013. PMID: 23596048 Free PMC article.
Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia.
Huuhtanen J, Bhattacharya D, Lönnberg T, Kankainen M, Kerr C, Theodoropoulos J, Rajala H, Gurnari C, Kasanen T, Braun T, Teramo A, Zambello R, Herling M, Ishida F, Kawakami T, Salmi M, Loughran T, Maciejewski JP, Lähdesmäki H, Kelkka T, Mustjoki S. Huuhtanen J, et al. Nat Commun. 2022 Apr 11;13(1):1981. doi: 10.1038/s41467-022-29173-z. Nat Commun. 2022. PMID: 35411050 Free PMC article.
Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis.
Savola P, Kelkka T, Rajala HL, Kuuliala A, Kuuliala K, Eldfors S, Ellonen P, Lagström S, Lepistö M, Hannunen T, Andersson EI, Khajuria RK, Jaatinen T, Koivuniemi R, Repo H, Saarela J, Porkka K, Leirisalo-Repo M, Mustjoki S. Savola P, et al. Among authors: rajala hl. Nat Commun. 2017 Jun 21;8:15869. doi: 10.1038/ncomms15869. Nat Commun. 2017. PMID: 28635960 Free PMC article.
Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998).
Loughran TP Jr, Zickl L, Olson TL, Wang V, Zhang D, Rajala HL, Hasanali Z, Bennett JM, Lazarus HM, Litzow MR, Evens AM, Mustjoki S, Tallman MS. Loughran TP Jr, et al. Among authors: rajala hl. Leukemia. 2015 Apr;29(4):886-94. doi: 10.1038/leu.2014.298. Epub 2014 Sep 13. Leukemia. 2015. PMID: 25306898 Free PMC article. Clinical Trial.
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