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An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R.
Fujita M, Ieguchi K, Cedano-Prieto DM, Fong A, Wilkerson C, Chen JQ, Wu M, Lo SH, Cheung AT, Wilson MD, Cardiff RD, Borowsky AD, Takada YK, Takada Y. Fujita M, et al. Among authors: borowsky ad. J Biol Chem. 2013 Jul 5;288(27):19593-603. doi: 10.1074/jbc.M113.470872. Epub 2013 May 21. J Biol Chem. 2013. PMID: 23696648 Free PMC article.
Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth.
Yen L, Cao Z, Wu X, Ingalla ER, Baron C, Young LJ, Gregg JP, Cardiff RD, Borowsky AD, Sweeney C, Carraway KL 3rd. Yen L, et al. Among authors: borowsky ad. Cancer Res. 2006 Dec 1;66(23):11279-86. doi: 10.1158/0008-5472.CAN-06-2319. Cancer Res. 2006. PMID: 17145873
173 results