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PCSK9 is a critical regulator of the innate immune response and septic shock outcome.
Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH. Walley KR, et al. Among authors: christie jd. Sci Transl Med. 2014 Oct 15;6(258):258ra143. doi: 10.1126/scitranslmed.3008782. Sci Transl Med. 2014. PMID: 25320235 Free PMC article. Clinical Trial.
ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.
Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, Christie JD. Meyer NJ, et al. Among authors: christie jd. Am J Respir Crit Care Med. 2011 May 15;183(10):1344-53. doi: 10.1164/rccm.201005-0701OC. Epub 2011 Jan 21. Am J Respir Crit Care Med. 2011. PMID: 21257790 Free PMC article.
Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.
Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H; Trauma ALI SNP Consortium (TASC) investigators. Christie JD, et al. PLoS One. 2012;7(1):e28268. doi: 10.1371/journal.pone.0028268. Epub 2012 Jan 25. PLoS One. 2012. PMID: 22295056 Free PMC article.
Inflammasome-regulated cytokines are critical mediators of acute lung injury.
Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, Massaro AF, Rogers A, Gazourian L, Nakahira K, Haspel JA, Landazury R, Eppanapally S, Christie JD, Meyer NJ, Ware LB, Christiani DC, Ryter SW, Baron RM, Choi AM. Dolinay T, et al. Among authors: christie jd. Am J Respir Crit Care Med. 2012 Jun 1;185(11):1225-34. doi: 10.1164/rccm.201201-0003OC. Epub 2012 Mar 29. Am J Respir Crit Care Med. 2012. PMID: 22461369 Free PMC article.
African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients.
Shashaty MG, Meyer NJ, Localio AR, Gallop R, Bellamy SL, Holena DN, Lanken PN, Kaplan S, Yarar D, Kawut SM, Feldman HI, Christie JD. Shashaty MG, et al. Among authors: christie jd. J Crit Care. 2012 Oct;27(5):496-504. doi: 10.1016/j.jcrc.2012.02.002. Epub 2012 May 15. J Crit Care. 2012. PMID: 22591570 Free PMC article.
SNP-set analysis replicates acute lung injury genetic risk factors.
Meyer NJ, Daye ZJ, Rushefski M, Aplenc R, Lanken PN, Shashaty MG, Christie JD, Feng R. Meyer NJ, et al. Among authors: christie jd. BMC Med Genet. 2012 Jun 28;13:52. doi: 10.1186/1471-2350-13-52. BMC Med Genet. 2012. PMID: 22742663 Free PMC article.
382 results