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5-Lipoxygenase pathway in experimental abdominal aortic aneurysms.
Bhamidipati CM, Whatling CA, Mehta GS, Meher AK, Hajzus VA, Su G, Salmon M, Upchurch GR Jr, Owens GK, Ailawadi G. Bhamidipati CM, et al. Among authors: whatling ca. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2669-78. doi: 10.1161/ATVBAHA.114.304016. Epub 2014 Oct 16. Arterioscler Thromb Vasc Biol. 2014. PMID: 25324573 Free PMC article.
Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans.
Haemmig S, Hashemi Gheinani A, Zaromytidou M, Siasos G, Coskun AU, Cormier MA, Gross DA, Wara AKMK, Antoniadis AP, Sun X, Sukhova GK, Welt FGP, Andreou I, Whatling C, Gan LM, Wikström J, Edelman ER, Libby P, Stone PH, Feinberg MW. Haemmig S, et al. Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1487-1503. doi: 10.1161/ATVBAHA.121.315896. Epub 2021 Feb 11. Arterioscler Thromb Vasc Biol. 2021. PMID: 33567868 Free PMC article.
Reply.
Delbosc S, Whatling C, Michel JB. Delbosc S, et al. J Vasc Surg. 2015 Nov;62(5):1386-7. doi: 10.1016/j.jvs.2015.03.030. J Vasc Surg. 2015. PMID: 26506281 No abstract available.
Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases.
Lemurell M, Ulander J, Winiwarter S, Dahlén A, Davidsson Ö, Emtenäs H, Broddefalk J, Swanson M, Hovdal D, Plowright AT, Pettersen A, Rydén-Landergren M, Barlind J, Llinas A, Herslöf M, Drmota T, Sigfridsson K, Moses S, Whatling C. Lemurell M, et al. J Med Chem. 2015 Jan 22;58(2):897-911. doi: 10.1021/jm501531v. Epub 2014 Dec 22. J Med Chem. 2015. PMID: 25478788
Development of a highly sensitive liquid chromatography-mass spectrometry method to quantify plasma leukotriene E4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man.
Löfgren L, Forsberg GB, Davidsson P, Eketjäll S, Whatling C. Löfgren L, et al. Prostaglandins Other Lipid Mediat. 2020 Oct;150:106463. doi: 10.1016/j.prostaglandins.2020.106463. Epub 2020 May 23. Prostaglandins Other Lipid Mediat. 2020. PMID: 32450304
Recent advances for FLAP inhibitors.
Pettersen D, Davidsson Ö, Whatling C. Pettersen D, et al. Bioorg Med Chem Lett. 2015 Jul 1;25(13):2607-12. doi: 10.1016/j.bmcl.2015.04.090. Epub 2015 May 6. Bioorg Med Chem Lett. 2015. PMID: 26004579 Review.
37 results