Crews CM - Search Results

1

Pharmacological targeting of the pseudokinase Her3.

Xie T, Lim SM, Westover KD, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Gurbani D, Tae HS, Riddle SM, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS. Xie T, et al. Among authors: crews cm. Nat Chem Biol. 2014 Dec;10(12):1006-12. doi: 10.1038/nchembio.1658. Epub 2014 Oct 19. Nat Chem Biol. 2014. PMID: 25326665 Free PMC article.

2

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics.

Schneekloth AR, Pucheault M, Tae HS, Crews CM. Schneekloth AR, et al. Among authors: crews cm. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5904-8. doi: 10.1016/j.bmcl.2008.07.114. Epub 2008 Jul 31. Bioorg Med Chem Lett. 2008. PMID: 18752944 Free PMC article.

3

Total synthesis and biological evaluation of tyroscherin.

Tae HS, Hines J, Schneekloth AR, Crews CM. Tae HS, et al. Among authors: crews cm. Org Lett. 2010 Oct 1;12(19):4308-11. doi: 10.1021/ol101801u. Org Lett. 2010. PMID: 20831175 Free PMC article.

4

Unexpected stereochemical tolerance for the biological activity of tyroscherin.

Tae HS, Hines J, Schneekloth AR, Crews CM. Tae HS, et al. Among authors: crews cm. Bioorg Med Chem. 2011 Mar 1;19(5):1708-13. doi: 10.1016/j.bmc.2011.01.027. Epub 2011 Jan 19. Bioorg Med Chem. 2011. PMID: 21315614 Free PMC article.

5

Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins.

Neklesa TK, Tae HS, Schneekloth AR, Stulberg MJ, Corson TW, Sundberg TB, Raina K, Holley SA, Crews CM. Neklesa TK, et al. Among authors: crews cm. Nat Chem Biol. 2011 Jul 3;7(8):538-43. doi: 10.1038/nchembio.597. Nat Chem Biol. 2011. PMID: 21725302 Free PMC article.

6

Identification of hydrophobic tags for the degradation of stabilized proteins.

Tae HS, Sundberg TB, Neklesa TK, Noblin DJ, Gustafson JL, Roth AG, Raina K, Crews CM. Tae HS, et al. Among authors: crews cm. Chembiochem. 2012 Mar 5;13(4):538-41. doi: 10.1002/cbic.201100793. Epub 2012 Jan 23. Chembiochem. 2012. PMID: 22271667 Free PMC article.

7

Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction.

Buckley DL, Van Molle I, Gareiss PC, Tae HS, Michel J, Noblin DJ, Jorgensen WL, Ciulli A, Crews CM. Buckley DL, et al. Among authors: crews cm. J Am Chem Soc. 2012 Mar 14;134(10):4465-8. doi: 10.1021/ja209924v. Epub 2012 Feb 27. J Am Chem Soc. 2012. PMID: 22369643 Free PMC article.

8

A HaloTag-based small molecule microarray screening methodology with increased sensitivity and multiplex capabilities.

Noblin DJ, Page CM, Tae HS, Gareiss PC, Schneekloth JS, Crews CM. Noblin DJ, et al. Among authors: crews cm. ACS Chem Biol. 2012 Dec 21;7(12):2055-63. doi: 10.1021/cb300453k. Epub 2012 Oct 11. ACS Chem Biol. 2012. PMID: 23013033 Free PMC article.

9

Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α.

Buckley DL, Gustafson JL, Van Molle I, Roth AG, Tae HS, Gareiss PC, Jorgensen WL, Ciulli A, Crews CM. Buckley DL, et al. Among authors: crews cm. Angew Chem Int Ed Engl. 2012 Nov 12;51(46):11463-7. doi: 10.1002/anie.201206231. Epub 2012 Oct 12. Angew Chem Int Ed Engl. 2012. PMID: 23065727 Free PMC article.

10

Targeted protein destabilization reveals an estrogen-mediated ER stress response.

Raina K, Noblin DJ, Serebrenik YV, Adams A, Zhao C, Crews CM. Raina K, et al. Among authors: crews cm. Nat Chem Biol. 2014 Nov;10(11):957-62. doi: 10.1038/nchembio.1638. Epub 2014 Sep 21. Nat Chem Biol. 2014. PMID: 25242550 Free PMC article.

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