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A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α.
Chen SJ, Hoffman NE, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang XQ, Song J, Barrero C, Shi Y, Kawasawa YI, Bayerl M, Sun T, Barbour M, Wang HG, Madesh M, Cheung JY, Miller BA. Chen SJ, et al. Among authors: hirschler laszkiewicz i. J Biol Chem. 2014 Dec 26;289(52):36284-302. doi: 10.1074/jbc.M114.620922. Epub 2014 Nov 12. J Biol Chem. 2014. PMID: 25391657 Free PMC article.
TRPC3 activation by erythropoietin is modulated by TRPC6.
Hirschler-Laszkiewicz I, Tong Q, Conrad K, Zhang W, Flint WW, Barber AJ, Barber DL, Cheung JY, Miller BA. Hirschler-Laszkiewicz I, et al. J Biol Chem. 2009 Feb 13;284(7):4567-81. doi: 10.1074/jbc.M804734200. Epub 2008 Dec 13. J Biol Chem. 2009. PMID: 19074769 Free PMC article.
Role of TRPM2 in cell proliferation and susceptibility to oxidative stress.
Chen SJ, Zhang W, Tong Q, Conrad K, Hirschler-Laszkiewicz I, Bayerl M, Kim JK, Cheung JY, Miller BA. Chen SJ, et al. Am J Physiol Cell Physiol. 2013 Mar;304(6):C548-60. doi: 10.1152/ajpcell.00069.2012. Epub 2013 Jan 9. Am J Physiol Cell Physiol. 2013. PMID: 23302782 Free PMC article.
The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury.
Miller BA, Wang J, Hirschler-Laszkiewicz I, Gao E, Song J, Zhang XQ, Koch WJ, Madesh M, Mallilankaraman K, Gu T, Chen SJ, Keefer K, Conrad K, Feldman AM, Cheung JY. Miller BA, et al. Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H1010-22. doi: 10.1152/ajpheart.00906.2012. Epub 2013 Feb 1. Am J Physiol Heart Circ Physiol. 2013. PMID: 23376831 Free PMC article.
TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.
Miller BA, Hoffman NE, Merali S, Zhang XQ, Wang J, Rajan S, Shanmughapriya S, Gao E, Barrero CA, Mallilankaraman K, Song J, Gu T, Hirschler-Laszkiewicz I, Koch WJ, Feldman AM, Madesh M, Cheung JY. Miller BA, et al. Among authors: hirschler laszkiewicz i. J Biol Chem. 2014 Mar 14;289(11):7615-29. doi: 10.1074/jbc.M113.533851. Epub 2014 Feb 3. J Biol Chem. 2014. PMID: 24492610 Free PMC article.
Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.
Hoffman NE, Miller BA, Wang J, Elrod JW, Rajan S, Gao E, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Koch WJ, Feldman AM, Madesh M, Cheung JY. Hoffman NE, et al. Among authors: hirschler laszkiewicz i. Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H637-50. doi: 10.1152/ajpheart.00720.2014. Epub 2015 Jan 9. Am J Physiol Heart Circ Physiol. 2015. PMID: 25576627 Free PMC article.
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