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A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α.
Chen SJ, Hoffman NE, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang XQ, Song J, Barrero C, Shi Y, Kawasawa YI, Bayerl M, Sun T, Barbour M, Wang HG, Madesh M, Cheung JY, Miller BA. Chen SJ, et al. Among authors: hoffman ne. J Biol Chem. 2014 Dec 26;289(52):36284-302. doi: 10.1074/jbc.M114.620922. Epub 2014 Nov 12. J Biol Chem. 2014. PMID: 25391657 Free PMC article.
TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.
Miller BA, Hoffman NE, Merali S, Zhang XQ, Wang J, Rajan S, Shanmughapriya S, Gao E, Barrero CA, Mallilankaraman K, Song J, Gu T, Hirschler-Laszkiewicz I, Koch WJ, Feldman AM, Madesh M, Cheung JY. Miller BA, et al. Among authors: hoffman ne. J Biol Chem. 2014 Mar 14;289(11):7615-29. doi: 10.1074/jbc.M113.533851. Epub 2014 Feb 3. J Biol Chem. 2014. PMID: 24492610 Free PMC article.
Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.
Hoffman NE, Miller BA, Wang J, Elrod JW, Rajan S, Gao E, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Koch WJ, Feldman AM, Madesh M, Cheung JY. Hoffman NE, et al. Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H637-50. doi: 10.1152/ajpheart.00720.2014. Epub 2015 Jan 9. Am J Physiol Heart Circ Physiol. 2015. PMID: 25576627 Free PMC article.
Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.
Shanmughapriya S, Rajan S, Hoffman NE, Zhang X, Guo S, Kolesar JE, Hines KJ, Ragheb J, Jog NR, Caricchio R, Baba Y, Zhou Y, Kaufman BA, Cheung JY, Kurosaki T, Gill DL, Madesh M. Shanmughapriya S, et al. Among authors: hoffman ne. Sci Signal. 2015 Mar 3;8(366):ra23. doi: 10.1126/scisignal.2005673. Sci Signal. 2015. PMID: 25737585 Free PMC article.
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.
Tomar D, Dong Z, Shanmughapriya S, Koch DA, Thomas T, Hoffman NE, Timbalia SA, Goldman SJ, Breves SL, Corbally DP, Nemani N, Fairweather JP, Cutri AR, Zhang X, Song J, Jaña F, Huang J, Barrero C, Rabinowitz JE, Luongo TS, Schumacher SM, Rockman ME, Dietrich A, Merali S, Caplan J, Stathopulos P, Ahima RS, Cheung JY, Houser SR, Koch WJ, Patel V, Gohil VM, Elrod JW, Rajan S, Madesh M. Tomar D, et al. Among authors: hoffman ne. Cell Rep. 2016 May 24;15(8):1673-85. doi: 10.1016/j.celrep.2016.04.050. Epub 2016 May 12. Cell Rep. 2016. PMID: 27184846 Free PMC article.
MICU1 motifs define mitochondrial calcium uniporter binding and activity.
Hoffman NE, Chandramoorthy HC, Shamugapriya S, Zhang X, Rajan S, Mallilankaraman K, Gandhirajan RK, Vagnozzi RJ, Ferrer LM, Sreekrishnanilayam K, Natarajaseenivasan K, Vallem S, Force T, Choi ET, Cheung JY, Madesh M. Hoffman NE, et al. Cell Rep. 2013 Dec 26;5(6):1576-1588. doi: 10.1016/j.celrep.2013.11.026. Epub 2013 Dec 12. Cell Rep. 2013. PMID: 24332854 Free PMC article.
145 results