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A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α.
Chen SJ, Hoffman NE, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang XQ, Song J, Barrero C, Shi Y, Kawasawa YI, Bayerl M, Sun T, Barbour M, Wang HG, Madesh M, Cheung JY, Miller BA. Chen SJ, et al. Among authors: zhang xq. J Biol Chem. 2014 Dec 26;289(52):36284-302. doi: 10.1074/jbc.M114.620922. Epub 2014 Nov 12. J Biol Chem. 2014. PMID: 25391657 Free PMC article.
The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury.
Miller BA, Wang J, Hirschler-Laszkiewicz I, Gao E, Song J, Zhang XQ, Koch WJ, Madesh M, Mallilankaraman K, Gu T, Chen SJ, Keefer K, Conrad K, Feldman AM, Cheung JY. Miller BA, et al. Among authors: zhang xq. Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H1010-22. doi: 10.1152/ajpheart.00906.2012. Epub 2013 Feb 1. Am J Physiol Heart Circ Physiol. 2013. PMID: 23376831 Free PMC article.
TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.
Miller BA, Hoffman NE, Merali S, Zhang XQ, Wang J, Rajan S, Shanmughapriya S, Gao E, Barrero CA, Mallilankaraman K, Song J, Gu T, Hirschler-Laszkiewicz I, Koch WJ, Feldman AM, Madesh M, Cheung JY. Miller BA, et al. Among authors: zhang xq. J Biol Chem. 2014 Mar 14;289(11):7615-29. doi: 10.1074/jbc.M113.533851. Epub 2014 Feb 3. J Biol Chem. 2014. PMID: 24492610 Free PMC article.
Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics.
Bao L, Chen SJ, Conrad K, Keefer K, Abraham T, Lee JP, Wang J, Zhang XQ, Hirschler-Laszkiewicz I, Wang HG, Dovat S, Gans B, Madesh M, Cheung JY, Miller BA. Bao L, et al. Among authors: zhang xq. J Biol Chem. 2016 Nov 18;291(47):24449-24464. doi: 10.1074/jbc.M116.747147. Epub 2016 Sep 30. J Biol Chem. 2016. PMID: 27694440 Free PMC article.
The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation.
Hirschler-Laszkiewicz I, Chen SJ, Bao L, Wang J, Zhang XQ, Shanmughapriya S, Keefer K, Madesh M, Cheung JY, Miller BA. Hirschler-Laszkiewicz I, et al. Among authors: zhang xq. Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C571-C586. doi: 10.1152/ajpcell.00098.2018. Epub 2018 Jul 18. Am J Physiol Cell Physiol. 2018. PMID: 30020827 Free PMC article.
Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy.
Chen SJ, Bao L, Keefer K, Shanmughapriya S, Chen L, Lee J, Wang J, Zhang XQ, Hirschler-Laszkiewicz I, Merali S, Merali C, Imamura Y, Dovat S, Madesh M, Cheung JY, Wang HG, Miller BA. Chen SJ, et al. Among authors: zhang xq. Cell Death Dis. 2020 Apr 20;11(4):247. doi: 10.1038/s41419-020-2454-8. Cell Death Dis. 2020. PMID: 32312983 Free PMC article.
1,694 results