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Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107.
Zhang K, Mir SA, Hightower CM, Miramontes-Gonzalez JP, Maihofer AX, Chen Y, Mahata SK, Nievergelt CM, Schork NJ, Freedman BI, Vaingankar SM, O'Connor DT. Zhang K, et al. Among authors: chen y. J Am Soc Nephrol. 2015 Aug;26(8):1816-25. doi: 10.1681/ASN.2014060537. Epub 2014 Nov 12. J Am Soc Nephrol. 2015. PMID: 25392232 Free PMC article.
Chromogranin A polymorphisms are associated with hypertensive renal disease.
Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton BA, Rana BK, Smith DW, Stridsberg M, Ward HJ, Mahata M, Mahata SK, Bowden DW, Hicks PJ, Freedman BI, Schork NJ, O'Connor DT. Salem RM, et al. Among authors: chen y. J Am Soc Nephrol. 2008 Mar;19(3):600-14. doi: 10.1681/ASN.2007070754. Epub 2008 Jan 30. J Am Soc Nephrol. 2008. PMID: 18235090 Free PMC article.
Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.
Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT. Chen Y, et al. J Am Coll Cardiol. 2008 Oct 28;52(18):1468-81. doi: 10.1016/j.jacc.2008.07.047. J Am Coll Cardiol. 2008. PMID: 19017515 Free PMC article.
Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis.
Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung MM, Zhang K, Stridsberg M, Ziegler MG, Hamilton BA, Lipkowitz MS, Taupenot L, Nievergelt C, Mahata SK, O'Connor DT. Chen Y, et al. J Am Soc Nephrol. 2009 Jul;20(7):1623-32. doi: 10.1681/ASN.2008111148. Epub 2009 Jun 11. J Am Soc Nephrol. 2009. PMID: 19520754 Free PMC article.
Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function.
Lillie EO, Mahata M, Khandrika S, Rao F, Bundey RA, Wen G, Chen Y, Taupenot L, Smith DW, Mahata SK, Ziegler MG, Cockburn M, Schork NJ, O'Connor DT. Lillie EO, et al. Among authors: chen y. Circulation. 2007 May 1;115(17):2282-91. doi: 10.1161/CIRCULATIONAHA.106.648345. Epub 2007 Apr 16. Circulation. 2007. PMID: 17438153
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis.
Fung MM, Chen Y, Lipkowitz MS, Salem RM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata SK, Schork NJ, Brophy VH, O'Connor DT; AASK Co-Investigators. Fung MM, et al. Among authors: chen y. Nephrol Dial Transplant. 2009 Dec;24(12):3677-86. doi: 10.1093/ndt/gfp471. Epub 2009 Sep 10. Nephrol Dial Transplant. 2009. PMID: 19745105 Free PMC article.
Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene.
Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata SK, O'Connor DT. Gayen JR, et al. Among authors: chen y. Circ Cardiovasc Genet. 2010 Oct;3(5):414-25. doi: 10.1161/CIRCGENETICS.109.924050. Epub 2010 Aug 20. Circ Cardiovasc Genet. 2010. PMID: 20729505 Free PMC article.
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