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OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Buchan S, Manzo T, Flutter B, Rogel A, Edwards N, Zhang L, Sivakumaran S, Ghorashian S, Carpenter B, Bennett C, Freeman GJ, Sykes M, Croft M, Al-Shamkhani A, Chakraverty R. Buchan S, et al. Among authors: ghorashian s. J Immunol. 2015 Jan 1;194(1):125-133. doi: 10.4049/jimmunol.1401644. Epub 2014 Nov 17. J Immunol. 2015. PMID: 25404365 Free PMC article.
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.
Flutter B, Edwards N, Fallah-Arani F, Henderson S, Chai JG, Sivakumaran S, Ghorashian S, Bennett CL, Freeman GJ, Sykes M, Chakraverty R. Flutter B, et al. Among authors: ghorashian s. J Clin Invest. 2010 Nov;120(11):3855-68. doi: 10.1172/JCI41446. Epub 2010 Oct 18. J Clin Invest. 2010. PMID: 20978352 Free PMC article.
Redirection to the bone marrow improves T cell persistence and antitumor functions.
Khan AB, Carpenter B, Santos E Sousa P, Pospori C, Khorshed R, Griffin J, Velica P, Zech M, Ghorashian S, Forrest C, Thomas S, Gonzalez Anton S, Ahmadi M, Holler A, Flutter B, Ramirez-Ortiz Z, Means TK, Bennett CL, Stauss H, Morris E, Lo Celso C, Chakraverty R. Khan AB, et al. Among authors: ghorashian s. J Clin Invest. 2018 May 1;128(5):2010-2024. doi: 10.1172/JCI97454. Epub 2018 Apr 9. J Clin Invest. 2018. PMID: 29485974 Free PMC article.
CD1a is rarely expressed in pediatric or adult relapsed/refractory T-ALL: implications for immunotherapy.
Leong S, Inglott S, Papaleonidopoulou F, Orfinada K, Ancliff P, Bartram J, Carpenter B, Fielding AK, Ghorashian S, Grandage V, Gupta R, Hough R, Khwaja A, Pavasovic V, Rao A, Samarasinghe S, Vora A, Mansour MR, O'Connor D. Leong S, et al. Among authors: ghorashian s. Blood Adv. 2020 Oct 13;4(19):4665-4668. doi: 10.1182/bloodadvances.2020002502. Blood Adv. 2020. PMID: 33002130 Free PMC article. No abstract available.
Immunotherapy with CD25/CD71-allodepleted T cells to improve T-cell reconstitution after matched unrelated donor hematopoietic stem cell transplant: a randomized trial.
Peggs KS, Albon SJ, Oporto Espuelas M, Irving C, Richardson R, Casanovas-Company J, Wallace R, Guvenel A, Ghorashian S, Collura A, Subramaniyam M, Flutter B, Popova B, Castro F, Lopes A, Champion K, Schofield O, Clifton-Hadley L, Taylor T, Farrell M, Adams S, Gilmour KC, Mackinnon S, Tholouli E, Amrolia PJ. Peggs KS, et al. Among authors: ghorashian s. Cytotherapy. 2023 Jan;25(1):82-93. doi: 10.1016/j.jcyt.2022.08.010. Epub 2022 Oct 9. Cytotherapy. 2023. PMID: 36220712 Free article. Clinical Trial.
CD34+-selected stem cell boost can safely improve cytopenias following CAR T-cell therapy.
Mullanfiroze K, Lazareva A, Chu J, Williams L, Burridge S, Silva J, Chiesa R, Rao K, Lucchini G, Ghorashian S, O'Reilly M, Carpenter B, Grandage V, Hough R, Roddie C, Amrolia PJ. Mullanfiroze K, et al. Among authors: ghorashian s. Blood Adv. 2022 Aug 23;6(16):4715-4718. doi: 10.1182/bloodadvances.2022007572. Blood Adv. 2022. PMID: 35790110 Free PMC article. No abstract available.
50 results