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Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A, Freeman-Mills L, Giner FC, Rodenas-Cuadrado P, Mallappa S, Clark S, Thomas H, Jeffery R, Poulsom R, Rodriguez-Justo M, Novelli M, Chetty R, Silver A, Sansom OJ, Greten FR, Wang LM, East JE, Tomlinson I, Leedham SJ. Davis H, et al. Among authors: leedham sj. Nat Med. 2015 Jan;21(1):62-70. doi: 10.1038/nm.3750. Epub 2014 Dec 1. Nat Med. 2015. PMID: 25419707 Free PMC article.
Intestinal stem cells.
Leedham SJ, Brittan M, McDonald SA, Wright NA. Leedham SJ, et al. J Cell Mol Med. 2005 Jan-Mar;9(1):11-24. doi: 10.1111/j.1582-4934.2005.tb00333.x. J Cell Mol Med. 2005. PMID: 15784161 Free PMC article. Review.
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.
Greaves LC, Preston SL, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D, Leedham SJ, Deheragoda M, Sasieni P, Novelli MR, Jankowski JA, Turnbull DM, Wright NA, McDonald SA. Greaves LC, et al. Among authors: leedham sj. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):714-9. doi: 10.1073/pnas.0505903103. Epub 2006 Jan 6. Proc Natl Acad Sci U S A. 2006. PMID: 16407113 Free PMC article.
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells.
McDonald SA, Greaves LC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Deheragoda M, Leedham SJ, Taylor RW, Lee CY, Preston SL, Lovell M, Hunt T, Elia G, Oukrif D, Harrison R, Novelli MR, Mitchell I, Stoker DL, Turnbull DM, Jankowski JA, Wright NA. McDonald SA, et al. Among authors: leedham sj. Gastroenterology. 2008 Feb;134(2):500-10. doi: 10.1053/j.gastro.2007.11.035. Epub 2007 Nov 28. Gastroenterology. 2008. PMID: 18242216
APC and the three-hit hypothesis.
Segditsas S, Rowan AJ, Howarth K, Jones A, Leedham S, Wright NA, Gorman P, Chambers W, Domingo E, Roylance RR, Sawyer EJ, Sieber OM, Tomlinson IP. Segditsas S, et al. Oncogene. 2009 Jan 8;28(1):146-55. doi: 10.1038/onc.2008.361. Epub 2008 Oct 6. Oncogene. 2009. PMID: 18836487
Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.
Gutierrez-Gonzalez L, Deheragoda M, Elia G, Leedham SJ, Shankar A, Imber C, Jankowski JA, Turnbull DM, Novelli M, Wright NA, McDonald SA. Gutierrez-Gonzalez L, et al. Among authors: leedham sj. J Pathol. 2009 Mar;217(4):489-96. doi: 10.1002/path.2502. J Pathol. 2009. PMID: 19156773
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