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Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A, Freeman-Mills L, Giner FC, Rodenas-Cuadrado P, Mallappa S, Clark S, Thomas H, Jeffery R, Poulsom R, Rodriguez-Justo M, Novelli M, Chetty R, Silver A, Sansom OJ, Greten FR, Wang LM, East JE, Tomlinson I, Leedham SJ. Davis H, et al. Among authors: poulsom r. Nat Med. 2015 Jan;21(1):62-70. doi: 10.1038/nm.3750. Epub 2014 Dec 1. Nat Med. 2015. PMID: 25419707 Free PMC article.
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.
Segditsas S, Sieber O, Deheragoda M, East P, Rowan A, Jeffery R, Nye E, Clark S, Spencer-Dene B, Stamp G, Poulsom R, Suraweera N, Silver A, Ilyas M, Tomlinson I. Segditsas S, et al. Among authors: poulsom r. Hum Mol Genet. 2008 Dec 15;17(24):3864-75. doi: 10.1093/hmg/ddn286. Epub 2008 Sep 9. Hum Mol Genet. 2008. PMID: 18782851 Free PMC article.
Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.
Humphries A, Cereser B, Gay LJ, Miller DS, Das B, Gutteridge A, Elia G, Nye E, Jeffery R, Poulsom R, Novelli MR, Rodriguez-Justo M, McDonald SA, Wright NA, Graham TA. Humphries A, et al. Among authors: poulsom r. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2490-9. doi: 10.1073/pnas.1220353110. Epub 2013 Jun 13. Proc Natl Acad Sci U S A. 2013. PMID: 23766371 Free PMC article.
The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands.
Lavery DL, Nicholson AM, Poulsom R, Jeffery R, Hussain A, Gay LJ, Jankowski JA, Zeki SS, Barr H, Harrison R, Going J, Kadirkamanathan S, Davis P, Underwood T, Novelli MR, Rodriguez-Justo M, Shepherd N, Jansen M, Wright NA, McDonald SA. Lavery DL, et al. Among authors: poulsom r. Gut. 2014 Dec;63(12):1854-63. doi: 10.1136/gutjnl-2013-306508. Epub 2014 Feb 18. Gut. 2014. PMID: 24550372 Free PMC article.
Sources of adult hepatic stem cells: haematopoietic.
Jeffery R, Poulsom R, Alison MR. Jeffery R, et al. Among authors: poulsom r. Methods Mol Biol. 2009;481:141-54. doi: 10.1007/978-1-59745-201-4_12. Methods Mol Biol. 2009. PMID: 19096804 Review.
The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.
Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E, McCart A, Mandir N, Silver A, Goodlad R, Stamp G, Cockman M, East P, Spencer-Dene B, Poulsom R, Wright N, Tomlinson I. Pollard P, et al. Among authors: poulsom r. Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13. doi: 10.1053/j.gastro.2009.02.058. Epub 2009 Feb 25. Gastroenterology. 2009. PMID: 19248780
255 results