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Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A, Freeman-Mills L, Giner FC, Rodenas-Cuadrado P, Mallappa S, Clark S, Thomas H, Jeffery R, Poulsom R, Rodriguez-Justo M, Novelli M, Chetty R, Silver A, Sansom OJ, Greten FR, Wang LM, East JE, Tomlinson I, Leedham SJ. Davis H, et al. Among authors: tomlinson i. Nat Med. 2015 Jan;21(1):62-70. doi: 10.1038/nm.3750. Epub 2014 Dec 1. Nat Med. 2015. PMID: 25419707 Free PMC article.
Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.
Novelli MR, Williamson JA, Tomlinson IP, Elia G, Hodgson SV, Talbot IC, Bodmer WF, Wright NA. Novelli MR, et al. Among authors: tomlinson ip. Science. 1996 May 24;272(5265):1187-90. doi: 10.1126/science.272.5265.1187. Science. 1996. PMID: 8638166
The mutation rate and cancer.
Tomlinson IP, Novelli MR, Bodmer WF. Tomlinson IP, et al. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14800-3. doi: 10.1073/pnas.93.25.14800. Proc Natl Acad Sci U S A. 1996. PMID: 8962135 Free PMC article.
Clinical and molecular features of the hereditary mixed polyposis syndrome.
Whitelaw SC, Murday VA, Tomlinson IP, Thomas HJ, Cottrell S, Ginsberg A, Bukofzer S, Hodgson SV, Skudowitz RB, Jass JR, Talbot IC, Northover JM, Bodmer WF, Solomon E. Whitelaw SC, et al. Among authors: tomlinson ip. Gastroenterology. 1997 Feb;112(2):327-34. doi: 10.1053/gast.1997.v112.pm9024286. Gastroenterology. 1997. PMID: 9024286
Molecular genetics of colon cancer.
Tomlinson I, Ilyas M, Novelli M. Tomlinson I, et al. Cancer Metastasis Rev. 1997 Jun;16(1-2):67-79. doi: 10.1023/a:1005744323215. Cancer Metastasis Rev. 1997. PMID: 9156280 Review.
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
Lamlum H, Ilyas M, Rowan A, Clark S, Johnson V, Bell J, Frayling I, Efstathiou J, Pack K, Payne S, Roylance R, Gorman P, Sheer D, Neale K, Phillips R, Talbot I, Bodmer W, Tomlinson I. Lamlum H, et al. Among authors: tomlinson i. Nat Med. 1999 Sep;5(9):1071-5. doi: 10.1038/12511. Nat Med. 1999. PMID: 10470088
790 results