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Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.
Crompton JG, Sukumar M, Roychoudhuri R, Clever D, Gros A, Eil RL, Tran E, Hanada K, Yu Z, Palmer DC, Kerkar SP, Michalek RD, Upham T, Leonardi A, Acquavella N, Wang E, Marincola FM, Gattinoni L, Muranski P, Sundrud MS, Klebanoff CA, Rosenberg SA, Fearon DT, Restifo NP. Crompton JG, et al. Among authors: michalek rd. Cancer Res. 2015 Jan 15;75(2):296-305. doi: 10.1158/0008-5472.CAN-14-2277. Epub 2014 Nov 28. Cancer Res. 2015. PMID: 25432172 Free PMC article.
Adaptive mitochondrial reprogramming and resistance to PI3K therapy.
Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC. Ghosh JC, et al. Among authors: michalek rd. J Natl Cancer Inst. 2015 Feb 3;107(3):dju502. doi: 10.1093/jnci/dju502. Print 2015 Mar. J Natl Cancer Inst. 2015. PMID: 25650317 Free PMC article.
Methed-up FOXOs can't in-Akt-ivate.
Michalek RD, Rathmell JC. Michalek RD, et al. Mol Cell. 2008 Oct 24;32(2):160-2. doi: 10.1016/j.molcel.2008.10.006. Mol Cell. 2008. PMID: 18951081 Free PMC article.
Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease.
James EL, Michalek RD, Pitiyage GN, de Castro AM, Vignola KS, Jones J, Mohney RP, Karoly ED, Prime SS, Parkinson EK. James EL, et al. Among authors: michalek rd. J Proteome Res. 2015 Apr 3;14(4):1854-71. doi: 10.1021/pr501221g. Epub 2015 Feb 26. J Proteome Res. 2015. PMID: 25690941 Free article.
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.
Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC. Michalek RD, et al. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18348-53. doi: 10.1073/pnas.1108856108. Epub 2011 Oct 31. Proc Natl Acad Sci U S A. 2011. PMID: 22042850 Free PMC article.
Metabolic regulation of T lymphocytes.
MacIver NJ, Michalek RD, Rathmell JC. MacIver NJ, et al. Among authors: michalek rd. Annu Rev Immunol. 2013;31:259-83. doi: 10.1146/annurev-immunol-032712-095956. Epub 2013 Jan 3. Annu Rev Immunol. 2013. PMID: 23298210 Free PMC article. Review.
The metabolic life and times of a T-cell.
Michalek RD, Rathmell JC. Michalek RD, et al. Immunol Rev. 2010 Jul;236:190-202. doi: 10.1111/j.1600-065X.2010.00911.x. Immunol Rev. 2010. PMID: 20636818 Free PMC article. Review.
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