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A new small molecule inhibitor of soluble guanylate cyclase.
Mota F, Gane P, Hampden-Smith K, Allerston CK, Garthwaite J, Selwood DL. Mota F, et al. Bioorg Med Chem. 2015 Sep 1;23(17):5303-10. doi: 10.1016/j.bmc.2015.07.074. Epub 2015 Aug 4. Bioorg Med Chem. 2015. PMID: 26264842 Free PMC article.
Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.
Hartzoulakis B, Rossiter S, Gill H, O'Hara B, Steinke E, Gane PJ, Hurtado-Guerrero R, Leiper JM, Vallance P, Rust JM, Selwood DL. Hartzoulakis B, et al. Among authors: gane pj. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3953-6. doi: 10.1016/j.bmcl.2007.04.095. Epub 2007 May 3. Bioorg Med Chem Lett. 2007. PMID: 17543521
HIV-1 capsid is involved in post-nuclear entry steps.
Chen NY, Zhou L, Gane PJ, Opp S, Ball NJ, Nicastro G, Zufferey M, Buffone C, Luban J, Selwood D, Diaz-Griffero F, Taylor I, Fassati A. Chen NY, et al. Among authors: gane pj. Retrovirology. 2016 Apr 23;13:28. doi: 10.1186/s12977-016-0262-0. Retrovirology. 2016. PMID: 27107820 Free PMC article.
Endothelial C-type natriuretic peptide maintains vascular homeostasis.
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock AS, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL, Ahluwalia A, Hobbs AJ. Moyes AJ, et al. Among authors: gane pj. J Clin Invest. 2014 Sep;124(9):4039-51. doi: 10.1172/JCI74281. Epub 2014 Aug 8. J Clin Invest. 2014. PMID: 25105365 Free PMC article.
25 results