Selwood DL - Search Results

1

2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion.

Sayer JR, Walldén K, Pesnot T, Campbell F, Gane PJ, Simone M, Koss H, Buelens F, Boyle TP, Selwood DL, Waksman G, Tabor AB. Sayer JR, et al. Among authors: selwood dl. Bioorg Med Chem. 2014 Nov 15;22(22):6459-70. doi: 10.1016/j.bmc.2014.09.036. Epub 2014 Sep 28. Bioorg Med Chem. 2014. PMID: 25438770 Free PMC article.

2

Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase.

Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC, Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G, Woo CK. Selwood DL, et al. J Med Chem. 2001 Jan 4;44(1):78-93. doi: 10.1021/jm001034k. J Med Chem. 2001. PMID: 11141091

3

Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase.

Rossiter S, Smith CL, Malaki M, Nandi M, Gill H, Leiper JM, Vallance P, Selwood DL. Rossiter S, et al. Among authors: selwood dl. J Med Chem. 2005 Jul 14;48(14):4670-8. doi: 10.1021/jm050187a. J Med Chem. 2005. PMID: 16000003

4

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.

Hartzoulakis B, Rossiter S, Gill H, O'Hara B, Steinke E, Gane PJ, Hurtado-Guerrero R, Leiper JM, Vallance P, Rust JM, Selwood DL. Hartzoulakis B, et al. Among authors: selwood dl. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3953-6. doi: 10.1016/j.bmcl.2007.04.095. Epub 2007 May 3. Bioorg Med Chem Lett. 2007. PMID: 17543521

5

Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones.

Clutterbuck LA, Posada CG, Visintin C, Riddall DR, Lancaster B, Gane PJ, Garthwaite J, Selwood DL. Clutterbuck LA, et al. Among authors: selwood dl. J Med Chem. 2009 May 14;52(9):2694-707. doi: 10.1021/jm801180p. J Med Chem. 2009. PMID: 19341281

6

Chemical fragments that hydrogen bond to Asp, Glu, Arg, and His side chains in protein binding sites.

Chan AW, Laskowski RA, Selwood DL. Chan AW, et al. Among authors: selwood dl. J Med Chem. 2010 Apr 22;53(8):3086-94. doi: 10.1021/jm901696w. J Med Chem. 2010. PMID: 20230000

7

Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.

Vozzolo L, Loh B, Gane PJ, Tribak M, Zhou L, Anderson I, Nyakatura E, Jenner RG, Selwood D, Fassati A. Vozzolo L, et al. J Biol Chem. 2010 Dec 10;285(50):39314-28. doi: 10.1074/jbc.M110.155275. Epub 2010 Oct 11. J Biol Chem. 2010. PMID: 20937817 Free PMC article.

8

Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA.

Gooding M, Tudzarova S, Worthington RJ, Kingsbury SR, Rebstock AS, Dube H, Simone MI, Visintin C, Lagos D, Quesada JM, Laman H, Boshoff C, Williams GH, Stoeber K, Selwood DL. Gooding M, et al. Among authors: selwood dl. Chem Biol Drug Des. 2012 Jan;79(1):9-21. doi: 10.1111/j.1747-0285.2011.01249.x. Epub 2011 Nov 4. Chem Biol Drug Des. 2012. PMID: 21981778

9

A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes.

Dube H, Selwood D, Malouitre S, Capano M, Simone MI, Crompton M. Dube H, et al. Biochem J. 2012 Feb 1;441(3):901-7. doi: 10.1042/BJ20111301. Biochem J. 2012. PMID: 22035570 Free PMC article.

10

Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization.

Lo AW, Van de Water K, Gane PJ, Chan AW, Steadman D, Stevens K, Selwood DL, Waksman G, Remaut H. Lo AW, et al. Among authors: selwood dl. J Antimicrob Chemother. 2014 Apr;69(4):1017-26. doi: 10.1093/jac/dkt467. Epub 2013 Dec 8. J Antimicrob Chemother. 2014. PMID: 24324225 Free PMC article.

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