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Cell surface-tethered IL-12 repolarizes the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy.
Sci Adv. 2022 Apr 29;8(17):eabi8075. doi: 10.1126/sciadv.abi8075. Epub 2022 Apr 27.
Sci Adv. 2022.
PMID: 35476449
Free PMC article.
Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.
Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2nd, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ.
Kariolis MS, et al. Among authors: jones ds 2nd.
J Clin Invest. 2017 Jan 3;127(1):183-198. doi: 10.1172/JCI85610. Epub 2016 Nov 28.
J Clin Invest. 2017.
PMID: 27893463
Free PMC article.
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An engineered dimeric fragment of hepatocyte growth factor is a potent c-MET agonist.
Liu CJ, Jones DS 2nd, Tsai PC, Venkataramana A, Cochran JR.
Liu CJ, et al. Among authors: jones ds 2nd.
FEBS Lett. 2014 Dec 20;588(24):4831-7. doi: 10.1016/j.febslet.2014.11.018. Epub 2014 Nov 21.
FEBS Lett. 2014.
PMID: 25451235
Free PMC article.
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An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.
Kariolis MS, Miao YR, Jones DS 2nd, Kapur S, Mathews II, Giaccia AJ, Cochran JR.
Kariolis MS, et al. Among authors: jones ds 2nd.
Nat Chem Biol. 2014 Nov;10(11):977-83. doi: 10.1038/nchembio.1636. Epub 2014 Sep 21.
Nat Chem Biol. 2014.
PMID: 25242553
Free PMC article.
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Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists.
Jones DS 2nd, Tsai PC, Cochran JR.
Jones DS 2nd, et al.
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13035-40. doi: 10.1073/pnas.1102561108. Epub 2011 Jul 25.
Proc Natl Acad Sci U S A. 2011.
PMID: 21788476
Free PMC article.
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