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A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB. Ohm JE, et al. Among authors: baylin sb. Nat Genet. 2007 Feb;39(2):237-42. doi: 10.1038/ng1972. Epub 2007 Jan 9. Nat Genet. 2007. PMID: 17211412 Free PMC article.
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.
Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L. Mali P, et al. Among authors: baylin sb. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402. Stem Cells. 2010. PMID: 20201064 Free PMC article.
Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells.
Ohm JE, Mali P, Van Neste L, Berman DM, Liang L, Pandiyan K, Briggs KJ, Zhang W, Argani P, Simons B, Yu W, Matsui W, Van Criekinge W, Rassool FV, Zambidis E, Schuebel KE, Cope L, Yen J, Mohammad HP, Cheng L, Baylin SB. Ohm JE, et al. Among authors: baylin sb. Cancer Res. 2010 Oct 1;70(19):7662-73. doi: 10.1158/0008-5472.CAN-10-1361. Epub 2010 Sep 14. Cancer Res. 2010. PMID: 20841480 Free PMC article.
Role of nuclear architecture in epigenetic alterations in cancer.
Easwaran HP, Baylin SB. Easwaran HP, et al. Among authors: baylin sb. Cold Spring Harb Symp Quant Biol. 2010;75:507-15. doi: 10.1101/sqb.2010.75.031. Epub 2011 Mar 29. Cold Spring Harb Symp Quant Biol. 2010. PMID: 21447817 Free PMC article.
Combining Epigenetic and Immunotherapy to Combat Cancer.
Chiappinelli KB, Zahnow CA, Ahuja N, Baylin SB. Chiappinelli KB, et al. Among authors: baylin sb. Cancer Res. 2016 Apr 1;76(7):1683-9. doi: 10.1158/0008-5472.CAN-15-2125. Epub 2016 Mar 17. Cancer Res. 2016. PMID: 26988985 Free PMC article. Review.
Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality.
Zimmerlin L, Park TS, Huo JS, Verma K, Pather SR, Talbot CC Jr, Agarwal J, Steppan D, Zhang YW, Considine M, Guo H, Zhong X, Gutierrez C, Cope L, Canto-Soler MV, Friedman AD, Baylin SB, Zambidis ET. Zimmerlin L, et al. Among authors: baylin sb. Development. 2016 Dec 1;143(23):4368-4380. doi: 10.1242/dev.138982. Epub 2016 Sep 22. Development. 2016. PMID: 27660325 Free PMC article.
571 results