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A systematic study of the effect of low pH acid treatment on anti-drug antibodies specific for a domain antibody therapeutic: Impact on drug tolerance, assay sensitivity and post-validation method assessment of ADA in clinical serum samples.
Kavita U, Duo J, Crawford SM, Liu R, Valcin J, Gleason C, Dong H, Gadkari S, Dodge RW, Pillutla RC, DeSilva BS. Kavita U, et al. J Immunol Methods. 2017 Sep;448:91-104. doi: 10.1016/j.jim.2017.06.002. Epub 2017 Jun 16. J Immunol Methods. 2017. PMID: 28625864
Development and validation of a liquid chromatography tandem mass spectrometry assay for the quantitation of a protein therapeutic in cynomolgus monkey serum.
Zhao Y, Liu G, Angeles A, Hamuro LL, Trouba KJ, Wang B, Pillutla RC, DeSilva BS, Arnold ME, Shen JX. Zhao Y, et al. Among authors: desilva bs. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:81-7. doi: 10.1016/j.jchromb.2015.02.007. Epub 2015 Feb 16. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25756208
An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study.
Myler H, Rangan VS, Wang J, Kozhich A, Cummings JA, Neely R, Dail D, Liu A, Wang B, Vezina HE, Freebern W, Sung MC, Passmore D, Deshpande S, Kempe T, Gu H, Saewert M, Manney A, Lute J, Zambito F, Wong RL, Piccoli SP, Aubry AF, Pillutla R, Arnold M, DeSilva B. Myler H, et al. Among authors: desilva b. Bioanalysis. 2015;7(13):1569-82. doi: 10.4155/bio.15.80. Bioanalysis. 2015. PMID: 26226308
112 results