Politi K - Search Results

1

Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer.

Meador CB, Jin H, de Stanchina E, Nebhan CA, Pirazzoli V, Wang L, Lu P, Vuong H, Hutchinson KE, Jia P, Chen X, Eisenberg R, Ladanyi M, Politi K, Zhao Z, Lovly CM, Cross DA, Pao W. Meador CB, et al. Among authors: politi k. Mol Cancer Ther. 2015 Feb;14(2):542-52. doi: 10.1158/1535-7163.MCT-14-0723. Epub 2014 Dec 4. Mol Cancer Ther. 2015. PMID: 25477325 Free PMC article.

2

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.

Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H. Pao W, et al. Among authors: politi k. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11. doi: 10.1073/pnas.0405220101. Epub 2004 Aug 25. Proc Natl Acad Sci U S A. 2004. PMID: 15329413 Free PMC article.

3

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.

Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Pao W, et al. PLoS Med. 2005 Mar;2(3):e73. doi: 10.1371/journal.pmed.0020073. Epub 2005 Feb 22. PLoS Med. 2005. PMID: 15737014 Free PMC article.

4

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.

Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Politi K, et al. Genes Dev. 2006 Jun 1;20(11):1496-510. doi: 10.1101/gad.1417406. Epub 2006 May 16. Genes Dev. 2006. PMID: 16705038 Free PMC article.

5

Oncogenes come of age.

Varmus H, Pao W, Politi K, Podsypanina K, Du YC. Varmus H, et al. Among authors: politi k. Cold Spring Harb Symp Quant Biol. 2005;70:1-9. doi: 10.1101/sqb.2005.70.039. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869733 Free PMC article. Review.

6

Update on epidermal growth factor receptor mutations in non-small cell lung cancer.

Riely GJ, Politi KA, Miller VA, Pao W. Riely GJ, et al. Clin Cancer Res. 2006 Dec 15;12(24):7232-41. doi: 10.1158/1078-0432.CCR-06-0658. Clin Cancer Res. 2006. PMID: 17189394 Review.

7

Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.

Regales L, Balak MN, Gong Y, Politi K, Sawai A, Le C, Koutcher JA, Solit DB, Rosen N, Zakowski MF, Pao W. Regales L, et al. Among authors: politi k. PLoS One. 2007 Aug 29;2(8):e810. doi: 10.1371/journal.pone.0000810. PLoS One. 2007. PMID: 17726540 Free PMC article.

8

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.

Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W. Gong Y, et al. Among authors: politi k. PLoS Med. 2007 Oct 9;4(10):e294. doi: 10.1371/journal.pmed.0040294. PLoS Med. 2007. PMID: 17927446 Free PMC article.

9

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.

Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA, Pao W. Regales L, et al. Among authors: politi ka. J Clin Invest. 2009 Oct;119(10):3000-10. doi: 10.1172/JCI38746. Epub 2009 Sep 14. J Clin Invest. 2009. PMID: 19759520 Free PMC article.

10

Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma.

Politi K, Fan PD, Shen R, Zakowski M, Varmus H. Politi K, et al. Dis Model Mech. 2010 Jan-Feb;3(1-2):111-9. doi: 10.1242/dmm.003681. Epub 2009 Dec 9. Dis Model Mech. 2010. PMID: 20007486 Free PMC article.

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