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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: hertel c. Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8. Nat Med. 2015. PMID: 25485909
5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.
Pierson PD, Fettes A, Freichel C, Gatti-McArthur S, Hertel C, Huwyler J, Mohr P, Nakagawa T, Nettekoven M, Plancher JM, Raab S, Richter H, Roche O, Rodríguez Sarmiento RM, Schmitt M, Schuler F, Takahashi T, Taylor S, Ullmer C, Wiegand R. Pierson PD, et al. Among authors: hertel c. J Med Chem. 2009 Jul 9;52(13):3855-68. doi: 10.1021/jm900409x. J Med Chem. 2009. PMID: 19456097
Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.
Peters JU, Kühne H, Dehmlow H, Grether U, Conte A, Hainzl D, Hertel C, Kratochwil NA, Otteneder M, Narquizian R, Panousis CG, Ricklin F, Röver S. Peters JU, et al. Among authors: hertel c. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5426-30. doi: 10.1016/j.bmcl.2010.07.108. Epub 2010 Jul 29. Bioorg Med Chem Lett. 2010. PMID: 20724150
G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.
Kratochwil NA, Gatti-McArthur S, Hoener MC, Lindemann L, Christ AD, Green LG, Guba W, Martin RE, Malherbe P, Porter RH, Slack JP, Winnig M, Dehmlow H, Grether U, Hertel C, Narquizian R, Panousis CG, Kolczewski S, Steward L. Kratochwil NA, et al. Among authors: hertel c. Curr Top Med Chem. 2011;11(15):1902-24. doi: 10.2174/156802611796391267. Curr Top Med Chem. 2011. PMID: 21470172
NGF ligand alters NGF signaling via p75(NTR) and trkA.
Niederhauser O, Mangold M, Schubenel R, Kusznir EA, Schmidt D, Hertel C. Niederhauser O, et al. Among authors: hertel c. J Neurosci Res. 2000 Aug 1;61(3):263-72. doi: 10.1002/1097-4547(20000801)61:3<263::AID-JNR4>3.0.CO;2-M. J Neurosci Res. 2000. PMID: 10900073
132 results