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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8.
Nat Med. 2015.
PMID: 25485909
Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.
Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.
Finan B, et al. Among authors: riboulet w.
Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.
Sci Transl Med. 2013.
PMID: 24174327
Clinical Trial.
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Preparation and characterization of albumin conjugates of a truncated peptide YY analogue for half-life extension.
Ehrlich GK, Michel H, Truitt T, Riboulet W, Pop-Damkov P, Goelzer P, Hainzl D, Qureshi F, Lueckel B, Danho W, Conde-Knape K, Konkar A.
Ehrlich GK, et al. Among authors: riboulet w.
Bioconjug Chem. 2013 Dec 18;24(12):2015-24. doi: 10.1021/bc400340z. Epub 2013 Nov 27.
Bioconjug Chem. 2013.
PMID: 24251972
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Semiautomated quantitative image analysis of glomerular immunohistochemistry markers desmin, vimentin, podocin, synaptopodin and WT-1 in acute and chronic rat kidney disease models.
Funk J, Ott V, Herrmann A, Rapp W, Raab S, Riboulet W, Vandjour A, Hainaut E, Benardeau A, Singer T, Jacobsen B.
Funk J, et al. Among authors: riboulet w.
Histochem Cell Biol. 2016 Mar;145(3):315-26. doi: 10.1007/s00418-015-1391-6. Epub 2015 Dec 15.
Histochem Cell Biol. 2016.
PMID: 26671788
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Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.
Martin RE, Aebi JD, Hornsperger B, Krebs HJ, Kuhn B, Kuglstatter A, Alker AM, Märki HP, Müller S, Burger D, Ottaviani G, Riboulet W, Verry P, Tan X, Amrein K, Mayweg AV.
Martin RE, et al. Among authors: riboulet w.
J Med Chem. 2015 Oct 22;58(20):8054-65. doi: 10.1021/acs.jmedchem.5b00851. Epub 2015 Oct 2.
J Med Chem. 2015.
PMID: 26403853
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Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
Liu Y, Wu J, Zhou M, Chen W, Li D, Wang Z, Hornsperger B, Aebi JD, Märki HP, Kuhn B, Wang L, Kuglstatter A, Benz J, Müller S, Hochstrasser R, Ottaviani G, Xin J, Kirchner S, Mohr S, Verry P, Riboulet W, Shen HC, Mayweg AV, Amrein K, Tan X.
Liu Y, et al. Among authors: riboulet w.
J Med Chem. 2020 Jul 9;63(13):6876-6897. doi: 10.1021/acs.jmedchem.0c00233. Epub 2020 Jun 25.
J Med Chem. 2020.
PMID: 32530624
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Estimating Unbound Drug Concentrations in Simulated Human Lung Fluid: Relevance to Lung Antibiotic PKPD.
Keemink J, Cantrill C, Riboulet W, Jurmanović S, Pavlovski I, Bissantz C.
Keemink J, et al. Among authors: riboulet w.
Mol Pharm. 2023 Jul 3;20(7):3578-3588. doi: 10.1021/acs.molpharmaceut.3c00208. Epub 2023 May 24.
Mol Pharm. 2023.
PMID: 37226078
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