Kulkarni AR - Search Results

1

The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.

Papke RL, Bagdas D, Kulkarni AR, Gould T, AlSharari SD, Thakur GA, Damaj MI. Papke RL, et al. Among authors: kulkarni ar. Neuropharmacology. 2015 Apr;91:34-42. doi: 10.1016/j.neuropharm.2014.12.002. Epub 2014 Dec 11. Neuropharmacology. 2015. PMID: 25497451 Free PMC article.

2

Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotinic acetylcholine receptors.

Thakur GA, Kulkarni AR, Deschamps JR, Papke RL. Thakur GA, et al. Among authors: kulkarni ar. J Med Chem. 2013 Nov 14;56(21):8943-7. doi: 10.1021/jm401267t. Epub 2013 Oct 25. J Med Chem. 2013. PMID: 24090443 Free PMC article.

3

The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface.

Papke RL, Horenstein NA, Kulkarni AR, Stokes C, Corrie LW, Maeng CY, Thakur GA. Papke RL, et al. Among authors: kulkarni ar. J Biol Chem. 2014 Feb 14;289(7):4515-31. doi: 10.1074/jbc.M113.524603. Epub 2013 Dec 20. J Biol Chem. 2014. PMID: 24362025 Free PMC article.

4

Microwave-assisted Expeditious and Efficient Synthesis of Cyclopentene Ring-fused Tetrahydroquinoline Derivatives Using Three-component Povarov Reaction.

Kulkarni AR, Thakur GA. Kulkarni AR, et al. Tetrahedron Lett. 2013 Nov 27;54(48):10.1016/j.tetlet.2013.09.107. doi: 10.1016/j.tetlet.2013.09.107. Tetrahedron Lett. 2013. PMID: 24421568 Free PMC article.

5

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s).

Kulkarni PM, Kulkarni AR, Korde A, Tichkule RB, Laprairie RB, Denovan-Wright EM, Zhou H, Janero DR, Zvonok N, Makriyannis A, Cascio MG, Pertwee RG, Thakur GA. Kulkarni PM, et al. Among authors: kulkarni ar. J Med Chem. 2016 Jan 14;59(1):44-60. doi: 10.1021/acs.jmedchem.5b01303. Epub 2015 Nov 28. J Med Chem. 2016. PMID: 26529344 Free PMC article.

6

Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.

Horenstein NA, Papke RL, Kulkarni AR, Chaturbhuj GU, Stokes C, Manther K, Thakur GA. Horenstein NA, et al. Among authors: kulkarni ar. J Biol Chem. 2016 Mar 4;291(10):5049-67. doi: 10.1074/jbc.M115.692392. Epub 2016 Jan 7. J Biol Chem. 2016. PMID: 26742843 Free PMC article.

7

Combination Nanopreparations of a Novel Proapoptotic Drug - NCL-240, TRAIL and siRNA.

Riehle R, Pattni B, Jhaveri A, Kulkarni A, Thakur G, Degterev A, Torchilin V. Riehle R, et al. Pharm Res. 2016 Jul;33(7):1587-601. doi: 10.1007/s11095-016-1899-z. Epub 2016 Mar 7. Pharm Res. 2016. PMID: 26951567

8

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.

Laprairie RB, Kulkarni AR, Kulkarni PM, Hurst DP, Lynch D, Reggio PH, Janero DR, Pertwee RG, Stevenson LA, Kelly ME, Denovan-Wright EM, Thakur GA. Laprairie RB, et al. Among authors: kulkarni ar, kulkarni pm. ACS Chem Neurosci. 2016 Jun 15;7(6):776-98. doi: 10.1021/acschemneuro.6b00041. Epub 2016 Apr 25. ACS Chem Neurosci. 2016. PMID: 27046127 Free PMC article.

9

The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.

Bagdas D, Wilkerson JL, Kulkarni A, Toma W, AlSharari S, Gul Z, Lichtman AH, Papke RL, Thakur GA, Damaj MI. Bagdas D, et al. Br J Pharmacol. 2016 Aug;173(16):2506-20. doi: 10.1111/bph.13528. Epub 2016 Jul 18. Br J Pharmacol. 2016. PMID: 27243753 Free PMC article.

10

Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model.

Pattni BS, Nagelli SG, Aryasomayajula B, Deshpande PP, Kulkarni A, Hartner WC, Thakur G, Degterev A, Torchilin VP. Pattni BS, et al. Pharm Res. 2016 Oct;33(10):2540-51. doi: 10.1007/s11095-016-1978-1. Epub 2016 Jun 28. Pharm Res. 2016. PMID: 27351426 Free PMC article.

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