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The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs.
Jones SP, Tang XL, Guo Y, Steenbergen C, Lefer DJ, Kukreja RC, Kong M, Li Q, Bhushan S, Zhu X, Du J, Nong Y, Stowers HL, Kondo K, Hunt GN, Goodchild TT, Orr A, Chang CC, Ockaili R, Salloum FN, Bolli R. Jones SP, et al. Among authors: zhu x. Circ Res. 2015 Feb 13;116(4):572-86. doi: 10.1161/CIRCRESAHA.116.305462. Epub 2014 Dec 11. Circ Res. 2015. PMID: 25499773 Free PMC article.
Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-{kappa}B-dependent pathway.
Li Q, Guo Y, Ou Q, Cui C, Wu WJ, Tan W, Zhu X, Lanceta LB, Sanganalmath SK, Dawn B, Shinmura K, Rokosh GD, Wang S, Bolli R. Li Q, et al. Among authors: zhu x. Circulation. 2009 Sep 29;120(13):1222-30. doi: 10.1161/CIRCULATIONAHA.108.778688. Epub 2009 Sep 14. Circulation. 2009. PMID: 19752329 Free PMC article.
Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences.
Li Q, Guo Y, Ou Q, Wu WJ, Chen N, Zhu X, Tan W, Yuan F, Dawn B, Luo L, Hunt GN, Bolli R. Li Q, et al. Among authors: zhu x. Basic Res Cardiol. 2011 Nov;106(6):1367-77. doi: 10.1007/s00395-011-0208-6. Epub 2011 Jul 22. Basic Res Cardiol. 2011. PMID: 21785893 Free PMC article.
Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice.
Guo Y, Flaherty MP, Wu WJ, Tan W, Zhu X, Li Q, Bolli R. Guo Y, et al. Among authors: zhu x. Basic Res Cardiol. 2012 Sep;107(5):288. doi: 10.1007/s00395-012-0288-y. Epub 2012 Aug 3. Basic Res Cardiol. 2012. PMID: 22864681 Free PMC article.
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