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The GAGOme: a cell-based library of displayed glycosaminoglycans.
Chen YH, Narimatsu Y, Clausen TM, Gomes C, Karlsson R, Steentoft C, Spliid CB, Gustavsson T, Salanti A, Persson A, Malmström A, Willén D, Ellervik U, Bennett EP, Mao Y, Clausen H, Yang Z. Chen YH, et al. Nat Methods. 2018 Nov;15(11):881-888. doi: 10.1038/s41592-018-0086-z. Epub 2018 Aug 13. Nat Methods. 2018. PMID: 30104636
Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection.
Bagdonaite I, Marinova IN, Rudjord-Levann AM, Pallesen EMH, King-Smith SL, Karlsson R, Rømer TB, Chen YH, Miller RL, Olofsson S, Nordén R, Bergström T, Dabelsteen S, Wandall HH. Bagdonaite I, et al. Among authors: chen yh. Nat Commun. 2023 Nov 2;14(1):7000. doi: 10.1038/s41467-023-42669-6. Nat Commun. 2023. PMID: 37919266 Free PMC article.
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells.
Tian W, Ye Z, Wang S, Schulz MA, Van Coillie J, Sun L, Chen YH, Narimatsu Y, Hansen L, Kristensen C, Mandel U, Bennett EP, Jabbarzadeh-Tabrizi S, Schiffmann R, Shen JS, Vakhrushev SY, Clausen H, Yang Z. Tian W, et al. Among authors: chen yh. Nat Commun. 2019 Apr 30;10(1):1785. doi: 10.1038/s41467-019-09809-3. Nat Commun. 2019. PMID: 31040271 Free PMC article.
The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models.
Davies SP, Mycroft-West CJ, Pagani I, Hill HJ, Chen YH, Karlsson R, Bagdonaite I, Guimond SE, Stamataki Z, De Lima MA, Turnbull JE, Yang Z, Vicenzi E, Skidmore MA, Khanim FL, Richardson A. Davies SP, et al. Among authors: chen yh. Front Pharmacol. 2021 Aug 6;12:660490. doi: 10.3389/fphar.2021.660490. eCollection 2021. Front Pharmacol. 2021. PMID: 34421587 Free PMC article.
Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain.
Schuurs ZP, Hammond E, Elli S, Rudd TR, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R, Chen YH, Bagdonaite I, Yang Z, Ahmed YA, Richard DJ, Turnbull J, Ferro V, Coombe DR, Gandhi NS. Schuurs ZP, et al. Among authors: chen yh. Comput Struct Biotechnol J. 2021;19:2806-2818. doi: 10.1016/j.csbj.2021.05.002. Epub 2021 May 4. Comput Struct Biotechnol J. 2021. PMID: 33968333 Free PMC article.
Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
Tree JA, Turnbull JE, Buttigieg KR, Elmore MJ, Coombes N, Hogwood J, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R, Chen YH, Yang Z, Spalluto CM, Staples KJ, Yates EA, Gray E, Singh D, Wilkinson T, Page CP, Carroll MW. Tree JA, et al. Among authors: chen yh. Br J Pharmacol. 2021 Feb;178(3):626-635. doi: 10.1111/bph.15304. Epub 2020 Dec 14. Br J Pharmacol. 2021. PMID: 33125711 Free PMC article.
Genetic glycoengineering in mammalian cells.
Narimatsu Y, Büll C, Chen YH, Wandall HH, Yang Z, Clausen H. Narimatsu Y, et al. Among authors: chen yh. J Biol Chem. 2021 Jan-Jun;296:100448. doi: 10.1016/j.jbc.2021.100448. Epub 2021 Feb 20. J Biol Chem. 2021. PMID: 33617880 Free PMC article. Review.
7,062 results