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Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.
Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Li A, et al. Among authors: machesky lm. Dev Cell. 2011 Oct 18;21(4):722-34. doi: 10.1016/j.devcel.2011.07.008. Epub 2011 Sep 15. Dev Cell. 2011. PMID: 21924960 Free PMC article.
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, McDermott EW, Sheahan K, Pedone K, Finn AJ, Groben PA, Thomas NE, Hao H, Carson C, Norman JC, Machesky LM, Gallagher WM, Jackson IJ, Van Kempen L, Beermann F, Der C, Larue L, Welch HC, Ozanne BW, Sansom OJ. Lindsay CR, et al. Among authors: machesky lm. Nat Commun. 2011 Nov 22;2:555. doi: 10.1038/ncomms1560. Nat Commun. 2011. PMID: 22109529 Free PMC article.
Rac1 in the driver's seat for melanoma.
Machesky LM, Sansom OJ. Machesky LM, et al. Pigment Cell Melanoma Res. 2012 Nov;25(6):762-4. doi: 10.1111/pcmr.12004. Pigment Cell Melanoma Res. 2012. PMID: 22882909 No abstract available.
Fascin 1 is dispensable for developmental and tumour angiogenesis.
Ma Y, Reynolds LE, Li A, Stevenson RP, Hodivala-Dilke KM, Yamashiro S, Machesky LM. Ma Y, et al. Among authors: machesky lm. Biol Open. 2013 Sep 19;2(11):1187-91. doi: 10.1242/bio.20136031. eCollection 2013. Biol Open. 2013. PMID: 24244855 Free PMC article.
Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes.
Li A, Morton JP, Ma Y, Karim SA, Zhou Y, Faller WJ, Woodham EF, Morris HT, Stevenson RP, Juin A, Jamieson NB, MacKay CJ, Carter CR, Leung HY, Yamashiro S, Blyth K, Sansom OJ, Machesky LM. Li A, et al. Among authors: machesky lm. Gastroenterology. 2014 May;146(5):1386-96.e1-17. doi: 10.1053/j.gastro.2014.01.046. Epub 2014 Jan 23. Gastroenterology. 2014. PMID: 24462734 Free PMC article.
A Rac1-independent role for P-Rex1 in melanoblasts.
Lindsay CR, Li A, Faller W, Ozanne B, Welch H, Machesky LM, Sansom OJ. Lindsay CR, et al. Among authors: machesky lm. J Invest Dermatol. 2015 Jan;135(1):314-318. doi: 10.1038/jid.2014.323. Epub 2014 Jul 30. J Invest Dermatol. 2015. PMID: 25075639 Free PMC article. No abstract available.
213 results