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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, McDermott EW, Sheahan K, Pedone K, Finn AJ, Groben PA, Thomas NE, Hao H, Carson C, Norman JC, Machesky LM, Gallagher WM, Jackson IJ, Van Kempen L, Beermann F, Der C, Larue L, Welch HC, Ozanne BW, Sansom OJ. Lindsay CR, et al. Among authors: sansom oj. Nat Commun. 2011 Nov 22;2:555. doi: 10.1038/ncomms1560. Nat Commun. 2011. PMID: 22109529 Free PMC article.
Rac1 in the driver's seat for melanoma.
Machesky LM, Sansom OJ. Machesky LM, et al. Among authors: sansom oj. Pigment Cell Melanoma Res. 2012 Nov;25(6):762-4. doi: 10.1111/pcmr.12004. Pigment Cell Melanoma Res. 2012. PMID: 22882909 No abstract available.
Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes.
Li A, Morton JP, Ma Y, Karim SA, Zhou Y, Faller WJ, Woodham EF, Morris HT, Stevenson RP, Juin A, Jamieson NB, MacKay CJ, Carter CR, Leung HY, Yamashiro S, Blyth K, Sansom OJ, Machesky LM. Li A, et al. Among authors: sansom oj. Gastroenterology. 2014 May;146(5):1386-96.e1-17. doi: 10.1053/j.gastro.2014.01.046. Epub 2014 Jan 23. Gastroenterology. 2014. PMID: 24462734 Free PMC article.
A Rac1-independent role for P-Rex1 in melanoblasts.
Lindsay CR, Li A, Faller W, Ozanne B, Welch H, Machesky LM, Sansom OJ. Lindsay CR, et al. Among authors: sansom oj. J Invest Dermatol. 2015 Jan;135(1):314-318. doi: 10.1038/jid.2014.323. Epub 2014 Jul 30. J Invest Dermatol. 2015. PMID: 25075639 Free PMC article. No abstract available.
Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.
Muinonen-Martin AJ, Susanto O, Zhang Q, Smethurst E, Faller WJ, Veltman DM, Kalna G, Lindsay C, Bennett DC, Sansom OJ, Herd R, Jones R, Machesky LM, Wakelam MJ, Knecht DA, Insall RH. Muinonen-Martin AJ, et al. Among authors: sansom oj. PLoS Biol. 2014 Oct 14;12(10):e1001966. doi: 10.1371/journal.pbio.1001966. eCollection 2014 Oct. PLoS Biol. 2014. PMID: 25313567 Free PMC article.
394 results