Chaikuad A - Search Results

1

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.

Kerr G, Sheldon H, Chaikuad A, Alfano I, von Delft F, Bullock AN, Harris AL. Kerr G, et al. Among authors: chaikuad a. Angiogenesis. 2015 Apr;18(2):209-17. doi: 10.1007/s10456-014-9457-y. Epub 2015 Jan 4. Angiogenesis. 2015. PMID: 25557927 Free PMC article.

2

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.

Chaikuad A, Froese DS, Berridge G, von Delft F, Oppermann U, Yue WW. Chaikuad A, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21028-33. doi: 10.1073/pnas.1113921108. Epub 2011 Dec 12. Proc Natl Acad Sci U S A. 2011. PMID: 22160680 Free PMC article.

3

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.

Chaikuad A, Pilka ES, De Riso A, von Delft F, Kavanagh KL, Vénien-Bryan C, Oppermann U, Yue WW. Chaikuad A, et al. BMC Struct Biol. 2012 Jun 21;12:14. doi: 10.1186/1472-6807-12-14. BMC Struct Biol. 2012. PMID: 22720794 Free PMC article.

4

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.

Chaikuad A, Alfano I, Kerr G, Sanvitale CE, Boergermann JH, Triffitt JT, von Delft F, Knapp S, Knaus P, Bullock AN. Chaikuad A, et al. J Biol Chem. 2012 Oct 26;287(44):36990-8. doi: 10.1074/jbc.M112.365932. Epub 2012 Sep 12. J Biol Chem. 2012. PMID: 22977237 Free PMC article.

5

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

Canning P, Cooper CDO, Krojer T, Murray JW, Pike ACW, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock AN. Canning P, et al. Among authors: chaikuad a. J Biol Chem. 2013 Mar 15;288(11):7803-7814. doi: 10.1074/jbc.M112.437996. Epub 2013 Jan 24. J Biol Chem. 2013. PMID: 23349464 Free PMC article.

6

A new class of small molecule inhibitor of BMP signaling.

Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN. Sanvitale CE, et al. Among authors: chaikuad a. PLoS One. 2013 Apr 30;8(4):e62721. doi: 10.1371/journal.pone.0062721. Print 2013. PLoS One. 2013. PMID: 23646137 Free PMC article.

7

Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.

Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A. Ferguson FM, et al. Among authors: chaikuad a. J Med Chem. 2013 Dec 27;56(24):10183-7. doi: 10.1021/jm401582c. Epub 2013 Dec 13. J Med Chem. 2013. PMID: 24304323 Free PMC article.

8

Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.

Horbelt D, Boergermann JH, Chaikuad A, Alfano I, Williams E, Lukonin I, Timmel T, Bullock AN, Knaus P. Horbelt D, et al. Among authors: chaikuad a. J Biol Chem. 2015 Feb 6;290(6):3390-404. doi: 10.1074/jbc.M114.604397. Epub 2014 Nov 3. J Biol Chem. 2015. PMID: 25368322 Free PMC article.

9

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.

Chaikuad A, Knapp S, von Delft F. Chaikuad A, et al. Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1627-39. doi: 10.1107/S1399004715007968. Epub 2015 Jul 28. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26249344 Free PMC article.

10

Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads.

Chaikuad A, Bullock AN. Chaikuad A, et al. Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11):a022111. doi: 10.1101/cshperspect.a022111. Cold Spring Harb Perspect Biol. 2016. PMID: 27549117 Free PMC article. Review.

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