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Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion.
Li P, Burke S, Wang J, Chen X, Ortiz M, Lee SC, Lu D, Campos L, Goulding D, Ng BL, Dougan G, Huntly B, Gottgens B, Jenkins NA, Copeland NG, Colucci F, Liu P. Li P, et al. Among authors: chen x. Science. 2010 Jul 2;329(5987):85-9. doi: 10.1126/science.1188063. Epub 2010 Jun 10. Science. 2010. PMID: 20538915 Free PMC article.
Bcl11a is essential for lymphoid development and negatively regulates p53.
Yu Y, Wang J, Khaled W, Burke S, Li P, Chen X, Yang W, Jenkins NA, Copeland NG, Zhang S, Liu P. Yu Y, et al. Among authors: chen x. J Exp Med. 2012 Dec 17;209(13):2467-83. doi: 10.1084/jem.20121846. Epub 2012 Dec 10. J Exp Med. 2012. PMID: 23230003 Free PMC article.
Oral estrogen receptor PROTAC® vepdegestrant (ARV-471) is highly efficacious as monotherapy and in combination with CDK4/6 or PI3K/mTOR pathway inhibitors in preclinical ER+ breast cancer models.
Gough SM, Flanagan JJ, Teh J, Andreoli M, Rousseau E, Pannone M, Bookbinder M, Willard R, Davenport K, Bortolon E, Cadelina G, Gordon D, Pizzano J, Macaluso J, Soto L, Corradi J, Digianantonio K, Drulyte I, Morgan A, Quinn C, Békés M, Ferraro C, Chen X, Wang G, Dong H, Wang J, Langley DR, Houston J, Gedrich R, Taylor IC. Gough SM, et al. Among authors: chen x. Clin Cancer Res. 2024 May 31. doi: 10.1158/1078-0432.CCR-23-3465. Online ahead of print. Clin Cancer Res. 2024. PMID: 38819400
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