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Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.
Hoffman NE, Miller BA, Wang J, Elrod JW, Rajan S, Gao E, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Koch WJ, Feldman AM, Madesh M, Cheung JY. Hoffman NE, et al. Among authors: madesh m. Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H637-50. doi: 10.1152/ajpheart.00720.2014. Epub 2015 Jan 9. Am J Physiol Heart Circ Physiol. 2015. PMID: 25576627 Free PMC article.
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.
Mallilankaraman K, Cárdenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenár T, Csordás G, Madireddi P, Yang J, Müller M, Miller R, Kolesar JE, Molgó J, Kaufman B, Hajnóczky G, Foskett JK, Madesh M. Mallilankaraman K, et al. Among authors: madesh m. Nat Cell Biol. 2012 Dec;14(12):1336-43. doi: 10.1038/ncb2622. Epub 2012 Nov 25. Nat Cell Biol. 2012. PMID: 23178883 Free PMC article.
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.
Gandhirajan RK, Meng S, Chandramoorthy HC, Mallilankaraman K, Mancarella S, Gao H, Razmpour R, Yang XF, Houser SR, Chen J, Koch WJ, Wang H, Soboloff J, Gill DL, Madesh M. Gandhirajan RK, et al. Among authors: madesh m. J Clin Invest. 2013 Feb;123(2):887-902. doi: 10.1172/JCI65647. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348743 Free PMC article.
The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury.
Miller BA, Wang J, Hirschler-Laszkiewicz I, Gao E, Song J, Zhang XQ, Koch WJ, Madesh M, Mallilankaraman K, Gu T, Chen SJ, Keefer K, Conrad K, Feldman AM, Cheung JY. Miller BA, et al. Among authors: madesh m. Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H1010-22. doi: 10.1152/ajpheart.00906.2012. Epub 2013 Feb 1. Am J Physiol Heart Circ Physiol. 2013. PMID: 23376831 Free PMC article.
Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart.
Vagnozzi RJ, Gatto GJ Jr, Kallander LS, Hoffman NE, Mallilankaraman K, Ballard VL, Lawhorn BG, Stoy P, Philp J, Graves AP, Naito Y, Lepore JJ, Gao E, Madesh M, Force T. Vagnozzi RJ, et al. Among authors: madesh m. Sci Transl Med. 2013 Oct 16;5(207):207ra141. doi: 10.1126/scitranslmed.3006479. Sci Transl Med. 2013. PMID: 24132636 Free PMC article.
176 results