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Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.
Hoffman NE, Miller BA, Wang J, Elrod JW, Rajan S, Gao E, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Koch WJ, Feldman AM, Madesh M, Cheung JY. Hoffman NE, et al. Among authors: miller ba. Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H637-50. doi: 10.1152/ajpheart.00720.2014. Epub 2015 Jan 9. Am J Physiol Heart Circ Physiol. 2015. PMID: 25576627 Free PMC article.
The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury.
Miller BA, Wang J, Hirschler-Laszkiewicz I, Gao E, Song J, Zhang XQ, Koch WJ, Madesh M, Mallilankaraman K, Gu T, Chen SJ, Keefer K, Conrad K, Feldman AM, Cheung JY. Miller BA, et al. Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H1010-22. doi: 10.1152/ajpheart.00906.2012. Epub 2013 Feb 1. Am J Physiol Heart Circ Physiol. 2013. PMID: 23376831 Free PMC article.
TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.
Miller BA, Hoffman NE, Merali S, Zhang XQ, Wang J, Rajan S, Shanmughapriya S, Gao E, Barrero CA, Mallilankaraman K, Song J, Gu T, Hirschler-Laszkiewicz I, Koch WJ, Feldman AM, Madesh M, Cheung JY. Miller BA, et al. J Biol Chem. 2014 Mar 14;289(11):7615-29. doi: 10.1074/jbc.M113.533851. Epub 2014 Feb 3. J Biol Chem. 2014. PMID: 24492610 Free PMC article.
Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics.
Bao L, Chen SJ, Conrad K, Keefer K, Abraham T, Lee JP, Wang J, Zhang XQ, Hirschler-Laszkiewicz I, Wang HG, Dovat S, Gans B, Madesh M, Cheung JY, Miller BA. Bao L, et al. Among authors: miller ba. J Biol Chem. 2016 Nov 18;291(47):24449-24464. doi: 10.1074/jbc.M116.747147. Epub 2016 Sep 30. J Biol Chem. 2016. PMID: 27694440 Free PMC article.
The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation.
Hirschler-Laszkiewicz I, Chen SJ, Bao L, Wang J, Zhang XQ, Shanmughapriya S, Keefer K, Madesh M, Cheung JY, Miller BA. Hirschler-Laszkiewicz I, et al. Among authors: miller ba. Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C571-C586. doi: 10.1152/ajpcell.00098.2018. Epub 2018 Jul 18. Am J Physiol Cell Physiol. 2018. PMID: 30020827 Free PMC article.
Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy.
Chen SJ, Bao L, Keefer K, Shanmughapriya S, Chen L, Lee J, Wang J, Zhang XQ, Hirschler-Laszkiewicz I, Merali S, Merali C, Imamura Y, Dovat S, Madesh M, Cheung JY, Wang HG, Miller BA. Chen SJ, et al. Among authors: miller ba. Cell Death Dis. 2020 Apr 20;11(4):247. doi: 10.1038/s41419-020-2454-8. Cell Death Dis. 2020. PMID: 32312983 Free PMC article.
392 results