Kamphorst JJ - Search Results

1

Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.

Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD. Kamphorst JJ, et al. Cancer Res. 2015 Feb 1;75(3):544-53. doi: 10.1158/0008-5472.CAN-14-2211. Cancer Res. 2015. PMID: 25644265 Free PMC article.

2

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.

Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D. Commisso C, et al. Among authors: kamphorst jj. Nature. 2013 May 30;497(7451):633-7. doi: 10.1038/nature12138. Epub 2013 May 12. Nature. 2013. PMID: 23665962 Free PMC article.

3

Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism.

Kamphorst JJ, Fan J, Lu W, White E, Rabinowitz JD. Kamphorst JJ, et al. Anal Chem. 2011 Dec 1;83(23):9114-22. doi: 10.1021/ac202220b. Epub 2011 Nov 4. Anal Chem. 2011. PMID: 22004349 Free PMC article.

4

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids.

Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, White EP, Thompson CB, Rabinowitz JD. Kamphorst JJ, et al. Proc Natl Acad Sci U S A. 2013 May 28;110(22):8882-7. doi: 10.1073/pnas.1307237110. Epub 2013 May 13. Proc Natl Acad Sci U S A. 2013. PMID: 23671091 Free PMC article.

5

Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux.

Fan J, Kamphorst JJ, Rabinowitz JD, Shlomi T. Fan J, et al. Among authors: kamphorst jj. J Biol Chem. 2013 Oct 25;288(43):31363-9. doi: 10.1074/jbc.M113.502740. Epub 2013 Sep 12. J Biol Chem. 2013. PMID: 24030823 Free PMC article.

6

Quantitative flux analysis reveals folate-dependent NADPH production.

Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD. Fan J, et al. Among authors: kamphorst jj. Nature. 2014 Jun 12;510(7504):298-302. doi: 10.1038/nature13236. Epub 2014 May 4. Nature. 2014. PMID: 24805240 Free PMC article.

7

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate.

Kamphorst JJ, Chung MK, Fan J, Rabinowitz JD. Kamphorst JJ, et al. Cancer Metab. 2014 Dec 11;2:23. doi: 10.1186/2049-3002-2-23. eCollection 2014. Cancer Metab. 2014. PMID: 25671109 Free PMC article.

8

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.

Rajeshkumar NV, Dutta P, Yabuuchi S, de Wilde RF, Martinez GV, Le A, Kamphorst JJ, Rabinowitz JD, Jain SK, Hidalgo M, Dang CV, Gillies RJ, Maitra A. Rajeshkumar NV, et al. Among authors: kamphorst jj. Cancer Res. 2015 Aug 15;75(16):3355-64. doi: 10.1158/0008-5472.CAN-15-0108. Epub 2015 Jun 25. Cancer Res. 2015. PMID: 26113084 Free PMC article.

9

Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.

Rajeshkumar NV, Yabuuchi S, Pai SG, De Oliveira E, Kamphorst JJ, Rabinowitz JD, Tejero H, Al-Shahrour F, Hidalgo M, Maitra A, Dang CV. Rajeshkumar NV, et al. Among authors: kamphorst jj. Clin Cancer Res. 2017 Sep 15;23(18):5639-5647. doi: 10.1158/1078-0432.CCR-17-1115. Epub 2017 Jun 13. Clin Cancer Res. 2017. PMID: 28611197 Free PMC article.

10

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis.

Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, Snyder E, Santanam U, Dipaola RS, Jacks T, Rabinowitz JD, White E. Guo JY, et al. Among authors: kamphorst jj. Genes Dev. 2013 Jul 1;27(13):1447-61. doi: 10.1101/gad.219642.113. Genes Dev. 2013. PMID: 23824538 Free PMC article.

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