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The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma.
Barneda-Zahonero B, Collazo O, Azagra A, Fernández-Duran I, Serra-Musach J, Islam AB, Vega-García N, Malatesta R, Camós M, Gómez A, Román-González L, Vidal A, López-Bigas N, Villanueva A, Esteller M, Parra M. Barneda-Zahonero B, et al. Among authors: roman gonzalez l. Cell Death Dis. 2015 Feb 12;6(2):e1635. doi: 10.1038/cddis.2014.594. Cell Death Dis. 2015. PMID: 25675295 Free PMC article.
HDAC7 is a repressor of myeloid genes whose downregulation is required for transdifferentiation of pre-B cells into macrophages.
Barneda-Zahonero B, Román-González L, Collazo O, Rafati H, Islam AB, Bussmann LH, di Tullio A, De Andres L, Graf T, López-Bigas N, Mahmoudi T, Parra M. Barneda-Zahonero B, et al. Among authors: roman gonzalez l. PLoS Genet. 2013 May;9(5):e1003503. doi: 10.1371/journal.pgen.1003503. Epub 2013 May 16. PLoS Genet. 2013. PMID: 23696748 Free PMC article.
In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development.
Azagra A, Román-González L, Collazo O, Rodríguez-Ubreva J, de Yébenes VG, Barneda-Zahonero B, Rodríguez J, Castro de Moura M, Grego-Bessa J, Fernández-Duran I, Islam AB, Esteller M, Ramiro AR, Ballestar E, Parra M. Azagra A, et al. Among authors: roman gonzalez l. J Exp Med. 2016 Nov 14;213(12):2591-2601. doi: 10.1084/jem.20150821. Epub 2016 Oct 17. J Exp Med. 2016. PMID: 27810920 Free PMC article.