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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16.
Nat Med. 2015.
PMID: 25686105
Free PMC article.
IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells.
Sweeney CM, Lonergan R, Basdeo SA, Kinsella K, Dungan LS, Higgins SC, Kelly PJ, Costelloe L, Tubridy N, Mills KH, Fletcher JM.
Sweeney CM, et al. Among authors: dungan ls.
Brain Behav Immun. 2011 Aug;25(6):1170-81. doi: 10.1016/j.bbi.2011.03.007. Epub 2011 Mar 21.
Brain Behav Immun. 2011.
PMID: 21420486
Item in Clipboard
Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity.
Lalor SJ, Dungan LS, Sutton CE, Basdeo SA, Fletcher JM, Mills KH.
Lalor SJ, et al. Among authors: dungan ls.
J Immunol. 2011 May 15;186(10):5738-48. doi: 10.4049/jimmunol.1003597. Epub 2011 Apr 6.
J Immunol. 2011.
PMID: 21471445
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Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17.
Dungan LS, Mills KH.
Dungan LS, et al.
Cytokine. 2011 Oct;56(1):126-32. doi: 10.1016/j.cyto.2011.07.007. Epub 2011 Aug 6.
Cytokine. 2011.
PMID: 21824786
Review.
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The role of inflammasome-derived IL-1 in driving IL-17 responses.
Mills KH, Dungan LS, Jones SA, Harris J.
Mills KH, et al. Among authors: dungan ls.
J Leukoc Biol. 2013 Apr;93(4):489-97. doi: 10.1189/jlb.1012543. Epub 2012 Dec 27.
J Leukoc Biol. 2013.
PMID: 23271701
Review.
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Innate IFN-γ promotes development of experimental autoimmune encephalomyelitis: a role for NK cells and M1 macrophages.
Dungan LS, McGuinness NC, Boon L, Lynch MA, Mills KH.
Dungan LS, et al.
Eur J Immunol. 2014 Oct;44(10):2903-17. doi: 10.1002/eji.201444612. Epub 2014 Aug 19.
Eur J Immunol. 2014.
PMID: 25056715
Free article.
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Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation.
Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, Misiak A, Dungan LS, Sutton CE, Streubel G, Bracken AP, Mills KH.
Mielke LA, et al. Among authors: dungan ls.
J Exp Med. 2013 Jun 3;210(6):1117-24. doi: 10.1084/jem.20121588. Epub 2013 May 20.
J Exp Med. 2013.
PMID: 23690441
Free PMC article.
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Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells.
Galvin KC, Dyck L, Marshall NA, Stefanska AM, Walsh KP, Moran B, Higgins SC, Dungan LS, Mills KH.
Galvin KC, et al. Among authors: dungan ls.
Cancer Immunol Immunother. 2013 Jul;62(7):1273-82. doi: 10.1007/s00262-013-1432-8. Epub 2013 May 9.
Cancer Immunol Immunother. 2013.
PMID: 23657628
Free PMC article.
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