O'Neill LA - Search Results

1

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA. Coll RC, et al. Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16. Nat Med. 2015. PMID: 25686105 Free PMC article.

2

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.

Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA. Fitzgerald KA, et al. Nature. 2001 Sep 6;413(6851):78-83. doi: 10.1038/35092578. Nature. 2001. PMID: 11544529

3

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.

Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT. Rowe DC, et al. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6299-304. doi: 10.1073/pnas.0510041103. Epub 2006 Apr 7. Proc Natl Acad Sci U S A. 2006. PMID: 16603631 Free PMC article.

4

IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8.

Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME, Garlanda C, Mantovani A, O'Neill LA, Mills KH, Lynch MA. Costelloe C, et al. J Neurochem. 2008 Jun;105(5):1960-9. doi: 10.1111/j.1471-4159.2008.05304.x. Epub 2008 Feb 18. J Neurochem. 2008. PMID: 18284608 Free article.

5

New insights into the regulation of signalling by toll-like receptors and nod-like receptors.

Coll RC, O'Neill LA. Coll RC, et al. J Innate Immun. 2010;2(5):406-21. doi: 10.1159/000315469. Epub 2010 May 27. J Innate Immun. 2010. PMID: 20505309 Free article. Review.

6

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.

Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA. Masters SL, et al. Nat Immunol. 2010 Oct;11(10):897-904. doi: 10.1038/ni.1935. Epub 2010 Sep 12. Nat Immunol. 2010. PMID: 20835230 Free PMC article.

7

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome.

Masters SL, O'Neill LA. Masters SL, et al. Trends Mol Med. 2011 May;17(5):276-82. doi: 10.1016/j.molmed.2011.01.005. Epub 2011 Mar 2. Trends Mol Med. 2011. PMID: 21376667 Review.

8

The inflammasome in atherosclerosis and type 2 diabetes.

Masters SL, Latz E, O'Neill LA. Masters SL, et al. Sci Transl Med. 2011 May 4;3(81):81ps17. doi: 10.1126/scitranslmed.3001902. Sci Transl Med. 2011. PMID: 21543720

9

The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes.

Coll RC, Robertson A, Butler M, Cooper M, O'Neill LA. Coll RC, et al. PLoS One. 2011;6(12):e29539. doi: 10.1371/journal.pone.0029539. Epub 2011 Dec 22. PLoS One. 2011. PMID: 22216309 Free PMC article.

10

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?

Wen H, Ting JP, O'Neill LA. Wen H, et al. Nat Immunol. 2012 Mar 19;13(4):352-7. doi: 10.1038/ni.2228. Nat Immunol. 2012. PMID: 22430788 Free PMC article. Review.

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