Duffy R - Search Results

1

Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.

McKittrick BA, Caldwell JP, Bara T, Boykow G, Chintala M, Clader J, Czarniecki M, Courneya B, Duffy R, Fleming L, Giessert R, Greenlee WJ, Heap C, Hong L, Huang Y, Iserloh U, Josien H, Khan T, Korfmacher W, Liang X, Mazzola R, Mitra S, Moore K, Orth P, Rajagopalan M, Roy S, Sakwa S, Strickland C, Vaccaro H, Voigt J, Wang H, Wong J, Zhang R, Zych A. McKittrick BA, et al. Among authors: duffy r. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1592-6. doi: 10.1016/j.bmcl.2015.02.003. Epub 2015 Feb 10. Bioorg Med Chem Lett. 2015. PMID: 25728416

2

Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model.

Wang H, Duffy RA, Boykow GC, Chackalamannil S, Madison VS. Wang H, et al. J Med Chem. 2008 Apr 24;51(8):2439-46. doi: 10.1021/jm701519h. Epub 2008 Mar 26. J Med Chem. 2008. PMID: 18363352

3

Diaryl piperidines as CB1 receptor antagonists.

Scott JD, Li SW, Wang H, Xia Y, Jayne CL, Miller MW, Duffy RA, Boykow GC, Kowalski TJ, Spar BD, Stamford AW, Chackalamannil S, Lachowicz JE, Greenlee WJ. Scott JD, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1278-83. doi: 10.1016/j.bmcl.2009.11.075. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 20018510

4

Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists.

Wang Y, Chackalamannil S, Hu Z, McKittrick BA, Greenlee W, Ruperto V, Duffy RA, Lachowicz JE. Wang Y, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1087-91. doi: 10.1016/s0960-894x(02)00096-3. Bioorg Med Chem Lett. 2002. PMID: 11909724

5

Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists.

Wang Y, Chackalamannil S, Hu Z, Greenlee WJ, Clader J, Boyle CD, Kaminski JJ, Billard W, Binch H 3rd, Crosby G, Ruperto V, Duffy RA, Cohen-Williams M, Coffin VL, Cox KA, Grotz DE, Lachowicz JE. Wang Y, et al. J Med Chem. 2002 Dec 5;45(25):5415-8. doi: 10.1021/jm0255163. J Med Chem. 2002. PMID: 12459007

6

Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.

Clader JW, Billard W, Binch H 3rd, Chen LY, Crosby G Jr, Duffy RA, Ford J, Kozlowski JA, Lachowicz JE, Li S, Liu C, McCombie SW, Vice S, Zhou G, Greenlee WJ. Clader JW, et al. Bioorg Med Chem. 2004 Jan 15;12(2):319-26. doi: 10.1016/j.bmc.2003.11.005. Bioorg Med Chem. 2004. PMID: 14723952

7

Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists.

Palani A, Dugar S, Clader JW, Greenlee WJ, Ruperto V, Duffy RA, Lachowicz JE. Palani A, et al. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1791-4. doi: 10.1016/j.bmcl.2004.01.033. Bioorg Med Chem Lett. 2004. PMID: 15026073

8

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.

Wang Y, Chackalamannil S, Hu Z, Clader JW, Greenlee W, Billard W, Binch H, Crosby G, Ruperto V, Duffy RA, McQuade R, Lachowicz JE. Wang Y, et al. Among authors: duffy ra. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2247-50. doi: 10.1016/s0960-894x(00)00457-1. Bioorg Med Chem Lett. 2000. PMID: 11055330

9

Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.

Boyle CD, Chackalamannil S, Clader JW, Greenlee WJ, Josien HB, Kaminski JJ, Kozlowski JA, McCombie SW, Nazareno DV, Tagat JR, Wang Y, Zhou G, Billard W, Binch H, Crosby G, Cohen-Williams M, Coffin VL, Cox KA, Grotz DE, Duffy RA, Ruperto V, Lachowicz JE. Boyle CD, et al. Among authors: duffy ra. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2311-4. doi: 10.1016/s0960-894x(01)00435-8. Bioorg Med Chem Lett. 2001. PMID: 11527721

10

Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency.

Billard W, Binch H, Bratzler K, Chen LY, Crosby G Jr, Duffy RA, Dugar S, Lachowicz J, McQuade R, Pushpavanam P, Ruperto VB, Taylor LA, Clader JW. Billard W, et al. Among authors: duffy ra. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2209-12. doi: 10.1016/s0960-894x(00)00437-6. Bioorg Med Chem Lett. 2000. PMID: 11012031

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